Mpox (formerly known as monkeypox) is a global public health concern, given the recent outbreaks in non-endemic countries where little scientific evidence exists on the disease epidemiology. Oral lesions among mpox cases have been poorly reported. Our aim was to estimate the overall prevalence of oral manifestations among patients with mpox globally. In this systematic review and meta-analysis, an extensive literature search in PubMed, Scopus, Web of Science, Embase, Cochrane, and preprint servers (medRxiv, arXiv, bioRxiv, BioRN, ChiRxiv, ChiRN, and SSRN) and assessment of all published articles, conducted across the world, until Nov 15 2022 as per the PROSPERO registration protocol (CRD42022371249), was undertaken. Primary studies (case series, cross-sectional, retrospective, prospective designs) that reported the oral/oropharyngeal symptoms among laboratory-confirmed mpox cases were included. The characteristics of the study, information on the number of cases, and symptomatic status were extracted from the included studies. The quality of the included studies was assessed for bias. Random-effects meta-regression with DerSimonian & Laird estimator, and subgroup analyses were conducted using STATA (v17.0). The degree of funnel plot asymmetry was assessed using Egger's test when at least 10 estimates were available. The heterogeneity between studies was assessed using the I² statistic. The primary outcome was the pooled prevalence of oral manifestations in the examined population. 19 studies were included with 4042 laboratory-confirmed patients with mpox for qualitative and quantitative synthesis. The pooled prevalence of oral manifestations in the investigated population was 36.75% (95% confidence interval [CI]: 23.77-50.65). Heterogeneity was found to be high in the current meta-analysis (I² = 98.24%; p < 0.001). Subgroup analysis revealed a pooled prevalence of 39.96% (95% CI: 21.42-59.91) of sore throat, 24.80% (95% CI: 8.14-46.32) of mouth sore, 18.24% (95% CI: 0.34-52.54) of tonsillitis and 17.99% (95% CI: 15.66-20.43) of mouth rash from the included studies. Oral manifestations are common in patients with mpox, with variations in prevalence across the sites within the oral cavity, and geography of the studies. Healthcare workers should be wary of the oral signs and symptoms of mpox in endemic and high-risk areas. None.

Objective: To assess and compare the accuracy of 3D-printed digital models, orthognathic surgical splints, retainers or aligners, and implant surgical guides printed using various 3D printing technologies. Methods: The search comprised prospective and retrospective studies related to the accuracy of 3D-printed models, splints, implant surgical guides, and retainers/aligners in patients undergoing orthodontic and orthognathic surgical procedures. The outcomes were assessed in terms of linear measurements, degree of fit, and positional deviations in comparison to conventional plaster models and surgical acrylic splints. The methodologic quality of the articles and the level of evidence were assessed using the QUADAS-2 tool. A meta-analysis was performed to compare the accuracy of models printed by different technologies to plaster models using the random-effects model. Results: Twenty-one retrospective studies were included. Quality assessment of all included articles showed moderate risk of bias and no article was excluded. The systematic review showed that there were no significant differences between printed surgical splints, retainers/aligners compared, and the control group. Meta-analysis of six eligible studies showed that printed models had a general trend toward overestimation of linear measurements (mean difference = 0.22 mm; 95% confidence interval = – 0.09 to 0.36 mm, I² = 85%). Measurements made on digital light processing-printed models were significantly different than those made on plaster models. Conclusion: The mean difference of 0.22 mm in linear measurements made on 3D-printed models and plaster models was clinically acceptable. Among the various printing technologies, PolyJet and fused deposition modeling-printed models showed higher accuracy. The printed splints and retainers/aligners were as accurate and reliable as their respective gold standards. The findings should be interpreted with caution due to high level of heterogeneity. PROSPERO Registration Number: CRD42020175511

Objectives: To evaluate the success rate, treatment duration, and pain perceived during forced eruption of maxillary palatally impacted canines using the K9 and Ballista springs. Materials and Methods: Thirty unilateral palatal canine impactions of moderate and difficult category as determined by KPG index (score between 10 and 19) were enrolled. Group 1 comprised canine impactions managed with K9 springs, and Group 2 comprised Ballista springs. Block randomization and opaque sealed envelopes were used for allocation. The success rate and treatment duration (application of force to ligation of the impacted canine into the initial alignment archwire) were recorded. Pain perception was evaluated on a 10-point visual analogue scale (VAS) and modified McGill Pain Questionnaire. Chi-square test and Mann-Whitney U -test were used to compare the groups. Results: The success rate for eruption of palatally impacted canines was 100%. The average treatment duration was 296.13 ± 96.45 days and 311.93 ± 94.34 days, respectively for Group 1 and Group 2. VAS scale scores for pain were greater for Group 2 compared to Group1, and the differences were statistically significant at all time intervals except at T1. The frequency of none and mild pain was significantly greater at all time intervals in both groups. Conclusions: The impacted canines of moderate and difficult category were erupted with a 100% success rate and similar treatment duration with both interventions. The pain scores of Ballista springs were greater after 24 hours of force application.

Background: The Sella Turcica is a critical structure from an orthodontic perspective, and its morphological characteristics can help in understanding craniofacial deformities. However, accurately extracting Sella Turcica shapes can be challenging due to the indistinct edges and indefinite boundaries present in X-ray images. This study aimed to develop and validate an automated Sella Morphology Network (SellaMorph-Net), a hybrid deep learning pipeline for segmenting Sella Turcica structure and extracting different morphological types; Methods: The SellaMorph-Net model proposed in this study combined attention-gating and recurrent residual convolutional layers (AGM and RrCL) to enhance the encoder’s abilities. The model’s output was then passed through a squeeze-and-excitation (SE) module to improve the network’s robustness. In addition, dropout layers were added to the end of each convolution block to prevent overfitting. A Zero-shot classifier was employed for multiple classifications, and the model’s output layer used five colour codes to represent different morphological types. The model’s performance was evaluated using various quantitative metrics, such as global accuracy and mean pixel-wise Intersection over Union (IoU) and dice coefficient, based on qualitative results; Results: The study collected 1653 radiographic images and categorised them into four classes based on the predefined shape of Sella Turcica. These classes were further divided into three subgroups based on the complexity of the Sella structures. The proposed SellaMorph-Net model achieved a global accuracy of 97.570, mean pixel-wise IoU scores of 0.7129, and a dice coefficient of 0.7324, significantly outperforming the VGG-19 and InceptionV3 models. The publicly available IEEE ISBI 2015 challenge dataset and our dataset were used to evaluate the test performance between the state-of-the-art and proposed models. The proposed model provided higher testing results, which were 0.7314 IoU and 0.7768 dice for our dataset and 0.7864 IoU and 0.8313 dice for the challenge dataset; Conclusions: The proposed hybrid SellaMorph-Net model provides an accurate and reliable pipeline for detecting morphological types of Sella Turcica using full lateral cephalometric images. Future work will focus on further improvement and utilisation of the developed model as a prognostic tool for predicting anomalies related to Sella structures.

To evaluate the impact of COVID-19 pandemic on orthodontic treatment and mental health of patients undergoing orthodontic treatment and to compare their mental health with the age-matched control group. 484 orthodontic patients (245 males and 239 females) and 200 age-matched control subjects were divided into two age groups. Group 1 had 14–18 years of adolescents (N = 274) and 100 control participants (Group 2) and Group 3 comprised of 19 years above adults (N = 210) and 100 control participants (Group 4). Group 1 and 3 patients filled the 4 sections of the questionnaire related to orthodontic emergencies (Sections 1-3) and mental distress (Kessler Psychological Distress Scale-Section 4), while groups 2 and 4 were asked to fill only Section-4. The comparison of mental distress on high/low Kessler scores was made using the Chi-Square test/Fisher's exact test. The factors which came out to be significant were put to bivariate logistic regression analysis. The percentage of patients with high Kessler scores among Group 1 and Group 3 were 9.9% and 17.2% respectively, and their differences with age-matched control groups were non-significant. The mean differences of Kessler score were significantly higher for Group 3 compared to group 1. The higher Kessler score was associated with age, higher education, a feeling of concern for non-availability of appointments, increased treatment duration, its effect on the quality of treatment, and sabotaging of definitive future plans. The orthodontic treatment and emergencies may not be a significant factor contributing to increased stress among patients during the lockdown.

Orthognathic surgery results in the positional change of the maxilla and mandible that may affect speech. The present study evaluated the effect of combined maxillary advancement and mandibular setback surgery on articulation proficiency and speech intelligibility in patients with non-syndromic skeletal Class III malocclusion. In this prospective study, twenty-five patients with skeletal class III malocclusion and consecutively treated with Lefort-1 maxillary advancement and mandibular setback (BSSO) orthognathic surgery were included in this study. The speech sample was recorded with a digital audio tape recorder one day before surgery and at 3, 6, 9, 12 and 18 months after surgery. Three qualified and experienced speech and language pathologists evaluated articulation errors and intelligibility of speech samples. Repeated One-way analysis of variance was used to compare articulation proficiency and speech intelligibility at different time intervals. The substitution, omission, distortion and addition errors showed no significant changes at 3 months and 6 months. The total articulation errors decreased to zero at 9 months and no significant increase was observed till 18 months (P < 0.05). Speech intelligibility showed statistically non-significant improvement at any time interval. Cephalometric skeletal parameters SNA and N ḻ A°. were significantly correlated with addition and total articulation errors at 18 months follow up. The ortho-surgical treatment improves speech (decreases. articulation errors) in most of the patients usually 6-9 months post-surgery. Speech intelligibility is not affected by bimaxillary orthognathic surgery in skeletal class III patients. The articulation errors were correlated to changes in position of maxilla.