Marital status and survival in epithelial ovarian cancer patients: a SEER-based study Marital status and survival in epithelial ovarian cancer patients: a SEER-based study

Large gaps exist between clinical practice and recommended care of breast cancer. Evidence demonstrates that assessment of breast cancer care can help bridge these gaps. However, no valid indicators are currently available for measurement of breast cancer care in China. This study aimed to develop a set of quality indicators to measure and improve the quality of breast cancer care. A modified Delphi process was implemented, and each of the six selection criteria (scientific evidence, utility, interpretability, validity, preventability and data availability) for potential indicators was evaluated on a 5-point scale. A 16-member expert panel was assembled, including 10 medical oncologists, 5 surgical oncologists and 1 radiation oncologist. Quality indicators with mean ratings ≥4, coefficient of variation equal to or <25% and selectivity ≥81.25% in each of the six selection criteria were retained for the face-to-face round. Twenty-six indicators were retained from the rating round and five indicators were retrieved in the face-to-face round. A total of 31 indicators constituted the final set of quality indicators, and the number of indicators pertaining to structure, process, communication and cooperation, management of symptoms or treatment toxicity and outcome was 1, 24, 2, 2 and 2, respectively. Quality indicators for breast cancer care can be systematically developed and will be utilized as a quality measurement tool for breast cancer care.

Biomarkers identification by a combined clinical and metabonomics analysis in Henoch-Schonlein purpura nephritis children Biomarkers identification by a combined clinical and metabonomics analysis in Henoch-Schonlein purpura nephritis children

Background and aim: Benchmarking is a management approach for implementing best medical practices at the lowest cost. The objectives of this study were to set achievable performance benchmarks for individual quality indicators to determine the predicted quality achievement related to better adherence, and to select optimal quality indicators for improving the quality of acute ischemic stroke care. Methods: We analyzed data on 500,331 patients diagnosed with acute ischemic stroke who were treated at 518 hospitals in China from January 2011 to May 2017. The primary outcome was independence (modified Rankin Scale score ≤2) at discharge. Data-driven achievable benchmarking used the “pared-mean” approach to set objective performance targets. Hierarchical logistic regression models were employed to evaluate the process–outcome association, as well as the predicted quality improvement if all hospitals were to operate at the benchmark level. Results: Of the overall population, 64.01% were independent patients at discharge. The performance benchmarks were >90% for most of the quality indicators. After adjusting for patient-level and hospital-level characteristics and unifying hospital performance to the benchmark level, the quality indicators with high increase in both overall adherence rate and independence rate were thrombolytic therapy, anticoagulant therapy, venous thrombosis prophylaxis. Conclusions: Performance targets for three acute treatments, including thrombolytic therapy, anticoagulant therapy, venous thrombosis prophylaxis, could best motivate improvements in both overall adherence rate and independence rate at discharge. The finding suggests that the above three types of acute treatment should be given priority to improve the quality of acute ischemic stroke care.

Background: The relationship between physical activity (PA) and bone health is well known, but the role of lean mass (LM) and fat mass (FM) in this relationship remains uncertain. Therefore, the aim of this study was to examine the mediating effect of LM and FM on the relationship between PA and bone mineral density (BMD) in postmenopausal women. Materials and Methods: This cross-sectional study involved 282 postmenopausal women aged between 50 and 65 year, who were randomly selected from Hongqi community of Harbin City in China. PA was measured using an International PA Questionnaire. Body composition, BMD of the lumbar spine, hip, and total body were measured using dual-energy X-ray absorptiometry. Mediation analysis was performed to investigate the mediating effect of LM and FM on the relationship between PA and BMD. Results: In partial correlation analysis, PA, LM, and FM were positively related to BMD. Positive correlation was found between PA and LM. There were significant differences in BMD between different categories of PA, but the differences disappeared after adjusting for LM. Mediation analysis showed that LM and FM played a mediating role in the relationship between PA and BMD. LM appeared to mediate the effect of BMD in the spine, hip, and total body by 26.91%, 19.55% and 47.98%, respectively; and FM was 22.23%, 27.97%, and 33.02%, respectively. Conclusion: LM and FM affected the relationship between PA and BMD as mediator. Postmenopausal women with high LM and FM had more BMD.