Chronic Kidney Disease (CKD) has become a major problem in modern times, and it is dubbed the silent assassin due to its delayed signs. To overcome these critical issues, early identification may minimize the prevalence of chronic diseases, though it is quite difficult because of different kinds of limitations in the dataset. The novelty of our study is that we extracted the best features from the dataset in order to provide the best classification models for diagnosing patients with chronic kidney disease. In our study, we used CKD patients’ clinical datasets to predict CKD using some popular machine learning algorithms. After handling missing values, K-means clustering has been performed. Then feature selection was done by applying the XGBoost feature selection algorithm. After selecting features from our dataset, we have used a variety of machine learning models to determine the best classification models, including Neural Network (NN), Random Forest (RF), Support Vector Machine (SVM), Random Tree (RT), and Bagging Tree Model (BTM). Accuracy, Sensitivity, Specificity, and Kappa values were used to evaluate model performance.

The study utilizes osteosarcoma hematoxylin and the Eosin-stained image dataset, which is unevenly dispersed, and it raises concerns about the potential impact on the overall performance and reliability of any analyses or models derived from the dataset. In this study, a deep-learning-based convolution neural network (CNN) and adapted heterogeneous ensemble-learning-based voting classifier have been proposed to classify osteosarcoma. The proposed methods can also resolve the issue and develop unbiased learning models by introducing an evenly distributed training dataset. Data augmentation is employed to boost the generalization abilities. Six different pre-trained CNN models, namely MobileNetV1, Mo-bileNetV2, ResNetV250, InceptionV2, EfficientNetV2B0, and NasNetMobile, are applied and evaluated in frozen and fine-tuned-based phases. In addition, a novel CNN model and adapted heterogeneous ensemble-learning-based voting classifier developed from the proposed CNN model, fine-tuned NasNetMobile model, and fine-tuned Efficient-NetV2B0 model are also introduced to classify osteosarcoma. The proposed CNN model outperforms other pre-trained models. The Kappa score obtained from the proposed CNN model is 93.09%. Notably, the proposed voting classifier attains the highest Kappa score of 96.50% and outperforms all other models. The findings of this study have practical implications in telemedicine, mobile healthcare systems, and as a supportive tool for medical professionals.