As artificial intelligence (AI) gains prominence in pathology and medicine, the ethical implications and potential biases within such integrated AI models will require careful scrutiny. Ethics and bias are important considerations in our practice settings, especially as an increased number of machine learning (ML) systems are being integrated within our various medical domains. Such ML-based systems have demonstrated remarkable capabilities in specified tasks such as, but not limited to, image recognition, natural language processing, and predictive analytics. However, the potential bias that may exist within such AI-ML models can also inadvertently lead to unfair and potentially detrimental outcomes. The source of bias within such ML models can be due to numerous factors but is typically categorized into 3 main buckets (data bias, development bias, and interaction bias). These could be due to the training data, algorithmic bias, feature engineering and selection issues, clinic and institutional bias (ie, practice variability), reporting bias, and temporal bias (ie, changes in technology, clinical practice, or disease patterns). Therefore, despite the potential of these AI-ML applications, their deployment in our day-to-day practice also raises noteworthy ethical concerns. To address ethics and bias in medicine, a comprehensive evaluation process is required, which will encompass all aspects of such systems, from model development through clinical deployment. Addressing these biases is crucial to ensure that AI-ML systems remain fair, transparent, and beneficial to all. This review will discuss the relevant ethical and bias considerations in AI-ML specifically within the pathology and medical domain.

Increased interest in the opportunities provided by artificial intelligence and machine learning has spawned a new field of health-care research. The new tools under development are targeting many aspects of medical practice, including changes to the practice of pathology and laboratory medicine. Optimal design in these powerful tools requires cross-disciplinary literacy, including basic knowledge and understanding of critical concepts that have traditionally been unfamiliar to pathologists and laboratorians. This review provides definitions and basic knowledge of machine learning categories (supervised, unsupervised, and reinforcement learning), introduces the underlying concept of the bias-variance trade-off as an important foundation in supervised machine learning, and discusses approaches to the supervised machine learning study design along with an overview and description of common supervised machine learning algorithms (linear regression, logistic regression, Naive Bayes, k-nearest neighbor, support vector machine, random forest, convolutional neural networks).

Artificial intelligence (AI) and machine learning (ML) are transforming the field of medicine. Health care organizations are now starting to establish management strategies for integrating such platforms (AI-ML toolsets) that leverage the computational power of advanced algorithms to analyze data and to provide better insights that ultimately translate to enhanced clinical decision-making and improved patient outcomes. Emerging AI-ML platforms and trends in pathology and medicine are reshaping the field by offering innovative solutions to enhance diagnostic accuracy, operational workflows, clinical decision support, and clinical outcomes. These tools are also increasingly valuable in pathology research in which they contribute to automated image analysis, biomarker discovery, drug development, clinical trials, and productive analytics. Other related trends include the adoption of ML operations for managing models in clinical settings, the application of multimodal and multiagent AI to utilize diverse data sources, expedited translational research, and virtualized education for training and simulation. As the final chapter of our AI educational series, this review article delves into the current adoption, future directions, and transformative potential of AI-ML platforms in pathology and medicine, discussing their applications, benefits, challenges, and future perspectives.

Machine learning (ML) is becoming an integral aspect of several domains in medicine. Yet, most pathologists and laboratory professionals remain unfamiliar with such tools and are unprepared for their inevitable integration. To bridge this knowledge gap, we present an overview of key elements within this emerging data science discipline. First, we will cover general, well-established concepts within ML, such as data type concepts, data preprocessing methods, and ML study design. We will describe common supervised and unsupervised learning algorithms and their associated common machine learning terms (provided within a comprehensive glossary of terms that are discussed within this review). Overall, this review will offer a broad overview of the key concepts and algorithms in machine learning, with a focus on pathology and laboratory medicine. The objective is to provide an updated useful reference for those new to this field or those who require a refresher.

In the realm of health care, numerous generative and nongenerative artificial intelligence and machine learning (AI-ML) tools have been developed and deployed. Simultaneously, manufacturers of medical devices are leveraging AI-ML. However, the adoption of AI in health care raises several concerns, including safety, security, ethical biases, accountability, trust, economic impact, and environmental effects. Effective regulation can mitigate some of these risks, promote fairness, establish standards, and advocate for more sustainable AI practices. Regulating AI tools not only ensures their safe and effective adoption but also fosters public trust. It is important that regulations remain flexible to accommodate rapid advances in this field to support innovation and also not to add additional burden to some of our preexisting and well-established frameworks. This study covers regional and global regulatory aspects of AI-ML including data privacy, software as a medical device, agency approval and clearance pathways, reimbursement, and laboratory-developed tests.

Artificial Intelligence (AI) and machine learning (ML) have now spawned a new field within health care and health science research. These new predictive analytics tools are starting to change various facets of our clinical care domains including the practice of laboratory medicine. Many of these ML tools and studies are also starting to populate our literature landscape as we know it but unfamiliarity of the average reader to the basic knowledge and critical concepts within AI/ML is now demanding a need to better prepare our audience to such relatively unfamiliar concepts. A fundamental knowledge of such platforms will inevitably enhance cross‐disciplinary literacy and ultimately lead to enhanced integration and understanding of such tools within our discipline. In this review, we provide a general outline of AI/ML along with an overview of the fundamental concepts of ML categories, specifically supervised, unsupervised, and reinforcement learning. Additionally, since the vast majority of our current approaches within ML in laboratory medicine and health care involve supervised algorithms, we will predominantly concentrate on such platforms. Finally, the need for making such tools more accessible to the average investigator is becoming a major driving force for the need of automation within these ML platforms. This has now given rise to the automated ML (Auto‐ML) world which will undoubtedly help shape the future of ML within health care. Hence, an overview of Auto‐ML is also covered within this manuscript which will hopefully enrich the reader's understanding, appreciation, and the need for embracing such tools.