Overhead hoist transportation systems (OHTS) have been the subject of worldwide research and development in recent years. The majority of these systems are utilized in semi-automated or fully automated factories. This article proposes a new solution for OTHS based on the concept of the modulation of mobile units that can move on a railway structure from one point to another. The OHTS mentioned in this article is a group of shuttles that can operate independently but which also have the ability to cooperate together to complete the desired tasks. By using the space below the ceiling, this system can operate without affecting the original design of the factories. There are many potential fields of application for picking-up and delivering, such as the medical field, the food and beverage fields, automotive and electrical appliances, etc. Moreover, by applying Dijkstra’s algorithm in the controller design, the transportation speed among the stations in the whole system can be improved. The real prototype of the whole system, including three shuttles, is also manufactured to explore and assess the design and operation of the proposed system and its controller.