Skin metastasis is the spread of malignant cells to the skin from a primary malignancy. It is quite uncommon for skin or cutaneous metastasis of internal malignancies to manifest as an initial presentation. It occurs in about 5.3% of patients with internal malignancies, representing 2% of all skin tumors. Lung cancer (LC) has the highest incidence and is the most common cause of cancer death worldwide. Metastasis to the skin should be carefully investigated to rule out a metastatic manifestation of an occult primary site tumor. It mostly occurs late in the course of the disease and indicates a poor prognosis. We report a case of a 65-year-old male presenting with multiple abdominal skin nodules as an initial uncommon presentation of unknown primary, along with a review of the literature for which we performed a Medline search for articles on cutaneous metastases from internal malignancies, including LC, using PubMed, and a manual search of pertinent references and textbooks.

Background: Fine-needle aspiration cytology (FNAC) is a minimally invasive tool for preoperative evaluation of palpable breast lesions. Cytological scoring systems—including the International Academy of Cytologists Yokohama System (YS), Masood Scoring Index (MSI), and Modified Masood Scoring Index (MMSI)—facilitate subcategorization of lesions and risk assessment. Aim: To classify breast FNAC smears according to YS, MSI, and MMSI and evaluate diagnostic performance through cytohistological concordance and other performance indicators. Materials and Methods: This retrospective cross-sectional study included 884 FNAC cases, out of which the cytohistological correlation was available in 682 cases from April 2020 to April 2024 at a tertiary care center in South India. Smears were categorized using YS, MSI, and MMSI. Sensitivity, specificity, positive predictive value, negative predictive value, diagnostic accuracy (DA), and Cohen’s kappa for concordance were calculated. Results: Mean patient age was 44.75 years (range 12–84), with a female-to-male ratio of 30:1. Cytohistological concordance was highest for MMSI (kappa = 0.874), followed by YS (0.853) and MSI (0.839). Intersystem concordance was highest between MMSI and MSI (0.884), followed by MMSI and YS (0.845), while it was lowest for MSI and YS (0.823). YS demonstrated the highest specificity (93.6%) and DA (95.5%) for malignant lesions. Risk of malignancy was highest in categories C4 and C5. Conclusion: MMSI shows superior concordance for benign and borderline lesions, while YS provides higher accuracy for malignant cases. Standardized reporting using these systems enhances reproducibility, facilitates clinical management, and aligns with lesion-specific risk stratification.