Candida is the largest genus of medically significant fungi. Although most of its members are commensals, residing harmlessly in human bodies, some are opportunistic and dangerously invasive. These have the ability to cause severe nosocomial candidiasis and candidemia that affect the viscera and bloodstream. A prompt diagnosis will lead to a successful treatment modality. The smart solution of biosensing technologies for rapid and precise detection of Candida species has made remarkable progress. The development of point-of-care (POC) biosensor devices involves sensor precision down to pico-/femtogram level, cost-effectiveness, portability, rapidity, and user-friendliness. However, futuristic diagnostics will depend on exploiting technologies such as multiplexing for high-throughput screening, CRISPR, artificial intelligence (AI), neural networks, the Internet of Things (IoT), and cloud computing of medical databases. This review gives an insight into different biosensor technologies designed for the detection of medically significant Candida species, especially Candida albicans and C. auris, and their applications in the medical setting.

The commonest cause of hepatic illness globally is non-alcoholic fatty liver disease (NAFLD). This multisystemic disease affects extrahepatic organs, including the heart. It causes cardiac remodeling and a disruption of the systolic and diastolic functioning of the left ventricle. Numerous studies have investigated the connection between NAFLD and left ventricular diastolic dysfunction (LVDD). The results, nevertheless, are often contradictory. This systematic review looked at the relationship between NAFLD and LVDD generally and among different patient groups since it is a topic of interest. A thorough search approach was used to locate relevant publications published between 2003 and 2023 using major medical databases. Studies were chosen based on the pre-established eligibility criteria; the studies selected then underwent a critical evaluation using standardized quality assessment tools. For the systematic review, 13 articles were chosen, comprising nine cross-sectional studies, three narrative reviews, and one meta-analysis. There were a total of 13,341 NAFLD patients in these studies. Data extraction and qualitative synthesis from the selected research articles were conducted to determine the relationship between NAFLD and LVDD in various patient categories. We found a significant association between NAFLD and LVDD. Therefore, patients with NAFLD should be treated early to avoid complications since they are more likely to develop cardiac dysfunction in the future.

Periodontitis, a chronic inflammatory disease of the gums affects both the ligament and alveolar bone. A severe form of periodontal disease affects a strikingly high number of one billion adults globally. The disease permutes both the soft and hard tissues of the oral cavity leading to localized and systemic diseases. Periodontitis has a deleterious impact on systemic health causing diabetes, cardiovascular diseases (CVD), and other disease. The cause of the enhanced inflammatory process is due to dysbiosis and an unregulated immune response. Innate immune response and T cells trigger uninhibited cytokine release causing an unwarranted inflammatory response. The RANK- RANKL interaction between osteoblasts, immune cells, and progenitor osteoclasts results in the maturation of osteoclasts, which promote bone resorption. It is well established that dysbiosis of the oral cavity has been implicated in periodontitis. But emerging reports suggest that the pulmonary pathogen, Mycobacterium tuberculosis (Mtb), causes extrapulmonary diseases such as periodontitis. Many clinical case reports advocate the involvement of Mtb in periodontitis, which poses a threat with the surge of tuberculosis in HIV and other immunocompromised individuals. Fostering a better understanding of the mechanism, causative agents and control on inflammatory response is imperative in the prevention and treatment of periodontitis.

This case report discusses a 13-year-old female with a known history of type 1 diabetes mellitus presenting with pain in bilateral lower limbs, generalized weakness, and fatigue. After laboratory examinations, hypoparathyroidism was diagnosed based on low serum calcium, elevated serum phosphorous, and lower serum intact parathyroid hormone (PTH) levels. Treatment with calcium and vitamin D supplements led to a reduction in the patient's symptoms. The report provides an overview of the pathophysiology of hypoparathyroidism, its various etiologies, and clinical manifestations. The report emphasizes the importance of considering hypoparathyroidism as a differential diagnosis in patients with unexplained neuromuscular symptoms, even without a known thyroid disease or previous thyroid surgery.

Purpose The complicated condition known as type 2 diabetes mellitus (T2DM) has a diverse genetic and environment-related cause. MIM125853 is among the heterogeneous diseases that can also be characterized as a multifactorial disorder of glucose metabolism with genetic susceptibility of an anomaly in the insulin pathway. We conducted the review with aim to assess the genetic variants affecting the insulin pathway as well as evaluate the risk of diabetes in association with genetic variants. Methods We used literature of 13 researches that met the inclusion criteria after the process of selection and analyzation. Our analysis included 59,593 participants in total with a gender distribution of 48% males (n = 24,591) and 52% females (n = 35,002). Result Gene variants such as PPARG, SLC30A8, KCNJ11, TCF7L2 and many others plays a pivotal role in the development of type-II diabetes as well as optimal functioning of insulin metabolic pathway for glucose metabolism and distribution with circulation. Conclusion KCNJ11 regulates insulin release in collaboration with other genes including ABCC8, KAPN10, IRS1 and TCF7L2. Reduced mutual expression of these kinds of genes could contribute to DM susceptibility. However, it is still unknown how precisely the combination of these genes’ functions in the control of insulin secretion.