Direction of arrival (DOA) is one of the essential topics in array signal processing that has many applications in communications, smart antennas, seismology, acoustics, radars, and many more. As the applications of DOA estimation are broadened, the challenges in implementing a DOA algorithm arise. Different environments require different modifications to the existing methods. This paper reviews the DOA algorithms in the literature. It evaluates and compares the performance of the three well known algorithms, including MUSIC, ESPRIT, and Eigenvalue Decomposition (EVD), with and without using adaptive directional time–frequency distributions (ADTFD) at the preprocessing stage. We simulated a case with four sources and three receivers. The sources were well separated. Signals were received at each sensor with an SNR value of −5 dB, 0 dB, 5 dB, and 10 dB. The angles of the sources were 15, 30, 45, and 60 degrees. The simulation results show that the ADTFD algorithm significantly improved the performance of MUSIC, while it did not provide similar results for the ESPRIT and EVD methods. As expected, the computation time of the algorithms was increased by implementing the ADTFD algorithm as a preprocessing step.

Cancer develops when a single or a group of cells grows and spreads uncontrollably. Histopathology images are used in cancer diagnosis since they show tissue and cell structures under a microscope. Knowledge-based and deep learning-based computer-aided detection is an ongoing research field in cancer diagnosis using histopathology images. Feature extraction is vital in both approaches since the feature set is fed to a classifier and determines the performance. This paper evaluates three feature extraction methods and their performance in breast cancer diagnosis. Features are extracted by (1) a Convolutional Neural Network, (2) a transfer learning architecture VGG16, and (3) a knowledge-based system. The feature sets are tested by seven classifiers, including Neural Network (64 units), Random Forest, Multilayer Perceptron, Decision Tree, Support Vector Machines, K-Nearest Neighbors, and Narrow Neural Network (10 units) on the BreakHis 400× image dataset. The CNN achieved up to 85% for the Neural Network and Random Forest, the VGG16 method achieved up to 86% for the Neural Network, and the knowledge-based features achieved up to 98% for Neural Network, Random Forest, Multilayer Perceptron classifiers.

Alzheimer's disease is a form of general dementia marked by amyloid plaques, neurofibrillary tangles, and neuron degeneration. The disease has no cure, and early detection is critical in improving patient outcomes. Magnetic resonance imaging (MRI) is important in measuring neurodegeneration during the disease. Computer-aided image processing tools have been used to aid medical professionals in ascertaining a diagnosis of Alzheimer's in its early stages. As characteristics of non and very-mild dementia stages overlap, tracking the progression is challenging. Our work developed an adaptive multi-thresholding algorithm based on the morphology of the smoothed histogram to define features identifying neurodegeneration and track its progression as non, very mild, mild, and moderate. Gray and white matter volume, statistical moments, multi-thresholds, shrinkage, gray-to-white matter ratio, and three distance and angle values are mathematically derived. Decision tree, discriminant analysis, Naïve Bayes, SVM, KNN, ensemble, and neural network classifiers are designed to evaluate the proposed methodology with the performance metrics accuracy, recall, specificity, precision, F1 score, Matthew’s correlation coefficient, and Kappa values. Experimental results showed that the proposed features successfully label the neurodegeneration stages.

Speaker age and gender classification is one of the most challenging problems in speech signal processing. Recently with developing technologies, identifying speaker age and gender information has become a necessity for speaker verification and identification systems such as identifying suspects in criminal cases, improving human–machine interaction, and adapting music for awaiting people queue. Despite the intensive studies that have been conducted to extract descriptive and distinctive features, the classification accuracies are still not satisfactory. In this work, a model for generating bottleneck features from a deep neural network and a Gaussian Mixture Model–Universal Background Model (GMM–UBM) classifier are proposed for speaker age and gender classification problem. Deep neural network with a bottleneck layer is trained in an unsupervised manner for calculating the initial weights between layers. Then, it is trained and tuned in a supervised manner to generate transformed mel-frequency cepstral coefficients (T-MFCCs). The GMM–UBM is used to build a GMM model for each class, and the models are used to classify speaker age and gender. Age-annotated database of German telephone speech (aGender) is used to evaluate the proposed classification system. The newly generated T-MFCCs have shown potential to achieve significant classification improvements in speaker age and gender classification by using the GMM–UBM classifier. The proposed classification system achieved an overall accuracy of 57.63%. The highest accuracy is calculated as 72.97% for adult female speakers.

Background: Pain is prevalent in almost all populations and may often hinder visual, auditory, tactile, olfactory, and taste perception as it alters brain neural processing. The quantitative methods emerging to define pain and assess its effects on neural functions and perception are important. Identifying pain biomarkers is one of the initial stages in developing such models and interventions. The existing literature has explored chronic and experimentally induced pain, leveraging electroencephalograms (EEGs) to identify biomarkers and employing various qualitative and quantitative approaches to measure pain. Objectives: This systematic review examines the methods, participant characteristics, types of pain states, associated pain biomarkers of the brain’s electrical activity, and limitations of current pain studies. The review identifies what experimental methods researchers implement to study human pain states compared to human control pain-free states, as well as the limitations in the current techniques of studying human pain states and future directions for research. Methods: The research questions were formed using the Population, Intervention, Comparison, Outcome (PICO) framework. A literature search was conducted using PubMed, PsycINFO, Embase, the Cochrane Library, IEEE Explore, Medline, Scopus, and Web of Science until December 2024, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to obtain relevant studies. The inclusion criteria included studies that focused on pain states and EEG data reporting. The exclusion criteria included studies that used only MEG or fMRI neuroimaging techniques and those that did not focus on the evaluation or assessment of neural markers. Bias risk was determined by the Newcastle–Ottawa Scale. Target data were compared between studies to organize the findings among the reported results. Results: The initial search resulted in 592 articles. After exclusions, 24 studies were included in the review, 6 of which focused on chronic pain populations. Experimentally induced pain methods were identified as techniques that centered on tactile perception: thermal, electrical, mechanical, and chemical. Across both chronic and stimulated pain studies, pain was associated with decreased or slowing peak alpha frequency (PAF). In the chronic pain studies, beta power increases were seen with pain intensity. The functional connectivity and pain networks of chronic pain patients differ from those of healthy controls; this includes the processing of experimental pain. Reportedly small sample sizes, participant comorbidities such as neuropsychiatric disorders and peripheral nerve damage, and uncontrolled studies were the common drawbacks of the studies. Standardizing methods and establishing collaborations to collect open-access comprehensive longitudinal data were identified as necessary future directions to generalize neuro markers of pain. Conclusions: This review presents a variety of experimental setups, participant populations, pain stimulation methods, lack of standardized data analysis methods, supporting and contradicting study findings, limitations, and future directions. Comprehensive studies are needed to understand the pain and brain relationship deeper in order to confirm or disregard the existing findings and to generalize biomarkers across chronic and experimentally induced pain studies. This requires the implementation of larger, diverse cohorts in longitudinal study designs, establishment of procedural standards, and creation of repositories. Additional techniques include the utilization of machine learning and analyzing data from long-term wearable EEG systems. The review protocol is registered on INPLASY (# 202520040).