Background: Many injection drug users (IDUs) in China have high risk sexual behaviors that contribute to the spread of HIV infection. Although many IDUs in China move through drug rehabilitation centers, this opportunity for sexual health education has largely been overlooked. Methods: A convenience sample of 667 drug users from two rehabilitation centers in South China was recruited in the study. Two hundred and forty seven drug users from a single Guangdong Province rehabilitation center received the peer-based education intervention, while 420 drug users from another rehabilitation center received routine HIV/STI education and was used as the control. One hundred and eighty nine (22.1%) individuals refused to participate in the study. HIV/STI behavioral and knowledge domains were assessed at 3 months in rehabilitation centers after the intervention (first follow-up) and at 2-23 months in the community after release (second follow-up). Results: Drug users who completed the intervention reported more frequent condom use with casual sex partners (60.0% vs. 12.5% condom use every time, p = 0.011) and less frequent injection (56.7% vs. 26.4% no injection per day, p = 0.008) at the second follow-up compared to those in the routine education group. Loss to follow up was substantial in both control and intervention groups, and was associated with living far from the detention center and having poor HIV knowledge at baseline. Conclusions: This study shows that rehabilitation centers may be a useful location for providing behavioral HIV/STI prevention services and referral of individuals to community-based programs upon release. More research is needed on behalf of detained drug users in China who have complex social, medical, and legal needs.

Background: Childhood obesity is a major public health challenge in the 21st century, and diet is one of the key modifiable factors in its prevention. This study examined the link between dietary patterns of children and general and central obesity, including the role of C-reactive protein (CRP). Methods: This study enrolled 2413 children aged 9–17. Anthropometric measurements, CRP levels, and dietary data were collected. Factor analysis identified dietary patterns, and logistic regression examined the association between CRP levels and childhood obesity. Multiple linear regression determined the correlation between dietary patterns and CRP. Mediation analysis assessed the role of CRP in the link between dietary patterns and childhood obesity. Results: Three dietary patterns were identified. The rice and meat pattern was significantly correlated to the risk of childhood obesity (OR = 1.166, 95%CI: 1.000, 1.359 for general obesity; OR = 1.215, 95%CI: 1.071, 1.377 for central obesity). CRP was positively correlated with childhood obesity risk (OR = 2.301, 95%CI: 1.776, 2.982 for general obesity; OR = 2.165, 95%CI: 1.738, 2.697 for central obesity). The fruit and vegetable pattern was inversely related to CRP (β= −0.059, 95%CI: −0.081, −0.036), while the snack pattern was positively correlated (β= 0.043, 95%CI: 0.020, 0.065). CRP had a suppressive effect on the association between the fruit and vegetable pattern and snack pattern with childhood obesity. Conclusions: This study revealed the rice and meat pattern as a risk factor for childhood obesity, and cross-sectional evidence linked the fruit and vegetable pattern and snack pattern to childhood obesity risk, mediated by CRP.

Hand, foot and mouth disease (HFMD) is a common infectious disease in children, and caregivers’ awareness of the disease is key to reducing its incidence. This study aims to investigate the Knowledge, Attitude, and Practice (KAP) levels of caregivers in Guangzhou regarding HFMD and to analyze the association of their demographic characteristics and family situations. This cross-sectional study used face-to-face interviews with caregivers of infants and toddlers to assess their KAP status regarding HFMD through a structured questionnaire. The dependent variables were the scores for KAP, while independent variables included caregivers’ demographic characteristics, household size, etc. Univariate analysis was performed initially to identify potential predictors, and variables with a P-value ≤ 0.10 were included in the multivariate logistic regression model. Adjusted odds ratios and 95% confidence intervals were calculated to determine the strength of associations, with statistical significance set at P ≤ 0.05. A total of 1,094 survey responses were included. Among the primary caregivers, 655 (59.87%) were mothers, 411 (37.57%) had a college degree or higher, and 298 (27.24%) were homemakers or unemployed. The scores for knowledge, attitude, and behavior were 5.6 ± 1.5 (range 0–8), 18.88 ± 3.44 (range 6–30), and 31.91 ± 4.14 (range 8–40). Caregivers show a relatively low level of concern regarding isolation measures and the risk of recurrent infections. The caregivers identity, age, education level, household size, number of children in childcare, place of residence, and history of illness were significantly associated with KAP levels. The primary caregivers generally exhibit good levels of knowledge and practices regarding HFMD, but the level of attitude is relatively low. Health promotion activities should be strengthened for caregivers who are elderly or have lower education levels, as well as for families with fewer permanent residents or those living in sub-central urban areas.