The multifunctional nanoplatform combining persistent luminescent nanoparticles (PLNPs) and metal–organic frameworks (MOFs) can be used for in vivo imaging and tumor therapy, providing a new strategy for effective tumor diagnosis and treatment.

A novel near-infrared persistent luminescent phosphor Na₂CaSn₂Ge₃O₁₂(NCSGO) doped with Ho³⁺, Er³⁺, Tm³⁺and Yb³⁺was synthesized by a high-temperature solid-state reaction.

The cause of Alzheimers disease, the most common type of dementia today, is still unclear, and in current research, there are no drugs that work relatively well. Therefore, the study for new drugs to treat Alzheimers disease is an urgent research need. Research on the improvement of Alzheimers disease with extracts of Xanthoceras sorbifolia has been increasing in recent years, but the mechanism is not fully understood. The experiments were conducted to validate the model and analyze the treatment effect through D-galactose and Aβ_25–35 induced dementia model mice, using the Morris water maze, to detect the learning behavior and brain tissue section to observe the hippocampal tissue structure of mice. We performed a nontargeted metabolomic analysis of the urine obtained from different groups of mice using gas chromatography-mass spectrometry. Fourteen potential biomarkers were identified in the mices urine, outlining five metabolic pathways of interest. It was shown that the extracts of Xanthoceras sorbifolia may exert protective effects on mice in dementia models through energy metabolism, neuroinflammation, and antioxidants. This study reveals the potential pathogenesis of Alzheimers disease and the possible therapeutic mechanism of Xanthoceras sorbifolia, suggests relevant biomarkers, and provides an additional basis for the clinical application of Xanthoceras sorbifolia.

Objective: We plan to review all published systematic reviews (SRs) and meta-analyses (MAs) of exercise or sport activities for patients with cancer. The aim of this study is to combine and reanalyze related data and to provide more comprehensive and higher-level evidence. Methods: We plan to search four English databases and four Chinese databases from inception to June 2019. Patients who were treated by all of exercise or sport activities such as running, gymnastics, taichi, and qigong, will be included. The following information will be extracted from each included SR: first author, year of publication, country of origin, number of primary study; the number of patients enrolled, participant characteristics, duration of cancer diagnosis, cancer types. Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and A Measurements Tool to Assess Systematic Reviews 2 (AMSTAR-2) will be used to assess the reporting and methodological quality of SRs/MAs. The characteristics of included SRs/MAs and their quality will be descriptively summarized using systematically structured tables. The network MA approach and narrative synthesis will be used to examine data when applicable. Odds ratio and (standardized) mean difference with their 95% confidence intervals will be used as summary statistics. Stata 13.0 software will be used to analyze and pool data. Results: The results of the overview will be submitted to a peer-reviewed journal for publication. Ethics and dissemination: The study is not a clinical study, and we will search and evaluate existing sources of literature. So, ethical approval is not required.

Objective: To study the changes in the vertical and sagittal craniomaxillofacial morphology in Chinese adult patients with bilateral anterior temporomandibular joint(TMJ)disc displacement and to explore their correlation. This may provide valuable insights for clinical diagnosis and treatment planning. Methods: Ninety-eight Chinese adult patients were divided into 3 groups: 29 patients in bilateral disc Normal Position group (BN), 33 patients in bilateral Anterior Disc Displacement With Reduction group (ADDWR) and 36 patients in bilateral Anterior Disc Displacement Without Reduction group (ADDWoR). Uceph software was used to measure 6 items of occlusal plane and 13 items of craniomaxillofacial morphology for comparison and correlation analysis between groups. Results: Compared to the BN group, subjects with anterior TMJ disc displacement (ADD) were more likely to exhibit a steeper posterior occlusal plane and an extended craniofacial posture with a Class II hyperdivergent pattern characteristics. Nevertheless, there were no statistically significant differences between the ADDWR and ADDWoR groups. The results of Pearson correlation analysis revealed a significant association between a steep occlusal plane in ADD patients and both skeletal mandibular retraction and vertical overgrowth. Conclusion: Chinese patients with anterior disc displacement of the TMJ have a steeper posterior occlusal plane and hyperdivergent skeletal Class II malocclusions tendency, which may be associated with occlusal function or condylar remodeling.