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19Years (2008-Present)
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Representative Publications
View All Publications18 January 2018 in Cell Death & Differentiation
Journal Article
MLMeiying Luo
Meiying Luo
LWLongfei Wu
Longfei Wu
KZKexin Zhang
Kexin Zhang
HWHong Wang
Hong Wang
TZTian Zhang
Tian Zhang
YYYongfei Yang
Yongfei Yang +6
Ferroptosis is a regulated form of cell death driven by small molecules or conditions that induce lipid-based reactive oxygen species (ROS) accumulation. This form of iron-dependent cell death is morphologically and genetically distinct from apoptosis, necroptosis, and autophagy. miRNAs are known to play crucial roles in diverse fundamental biological processes. However, to date no study has reported miRNA-mediated regulation of ferroptosis. Here we show that miR-137 negatively regulates ferroptosis by directly targeting glutamine transporter SLC1A5 in melanoma cells. Ectopic expression of miR-137 suppressed SLC1A5, resulting in decreased glutamine uptake and malondialdehyde (MDA) accumulation. Meanwhile, antagomir-mediated inactivation of endogenous miR-137 increased the sensitivity of melanoma cells to erastin- and RSL3-induced ferroptosis. Importantly, knockdown of miR-137 increased the antitumor activity of erastin by enhancing ferroptosis both in vitro and in vivo. Collectively, these data indicate that miR-137 plays a novel and indispensable role in ferroptosis by inhibiting glutaminolysis and suggest a potential therapeutic approach for melanoma.
23 January 2020 in Nature Communications
Journal Article
YYYongfei Yang
Yongfei YangMLMeiying Luo
Meiying Luo
KZKexin Zhang
Kexin ZhangJZJun Zhang
Jun Zhang
TGTongtong Gao
Tongtong Gao
WCWei Chen
Wei Chen +5
Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides. Erastin, the ferroptosis activator, binds to voltage-dependent anion channels VDAC2 and VDCA3, but treatment with erastin can result in the degradation of the channels. Here, the authors show that Nedd4 is induced following erastin treatment, which leads to the ubiquitination and subsequent degradation of the channels. Depletion of Nedd4 limits the protein degradation of VDAC2/3, which increases the sensitivity of cancer cells to erastin. By understanding the molecular mechanism of erastin-induced cellular resistance, we can discover how cells adapt to new molecules to maintain homeostasis. Furthermore, erastin-induced resistance mediated by FOXM1-Nedd4-VDAC2/3 negative feedback loop provides an initial framework for creating avenues to overcome the drug resistance of ferroptosis activators.
1 May 2020 in Chemical Engineering Journal
Journal Article
Yongfei YangJLJie Liu
Jie Liu
JYJun Yao
Jun Yao
JKJianlong Kou
Jianlong KouZLZheng LI
Zheng LIHSHai Sun
Hai Sun
+3
1 November 2015 in Journal of Natural Gas Science and Engineering
Journal Article
Yongfei YangJYJun Yao
Jun Yao
CWChenchen Wang
Chenchen Wang
YGYing Gao
Ying Gao
QZQi Zhang
Qi Zhang
WSWenhui Song
Wenhui Song
+1
1 October 2016 in Fuel
Journal Article
WSWenhui Song
Wenhui Song
JYJun Yao
Jun Yao
YLYang Li
Yang Li
Hai SunLZLei Zhang
Lei Zhang
HSHongguang Sui
Hongguang Sui
+2
1 September 2019 in Fuel
Journal Article
Yongfei YangKWKe Wang
Ke WangLZLei Zhang
Lei Zhang
HSHai Sun
Hai Sun
KZKai Zhang
Kai Zhang
JMJingsheng Ma
Jingsheng MaAbout Me
Yongfei Yang is a professor, vice dean of School of Petroleum Engineering at China University of Petroleum (East China). He is an active InterPore member, acting as secretary-general of China InterPore Chapter, secretary of InterPore Foundation and the Chair of Thematic Workshops Committee. He is the associate editor of Journal of Natural Gas Science and Engineering (JNGSE) and editorial board member of the Journal of Petroleum Science and Engineering (JPSE). He is also the co-chair of InterPore 2022 Qingdao Local Committee. He is also a life member of International Society of Core Analysts (SCA).
His research interests include theory and applications of fluid flow in porous media, the applications of digital rock and pore network model technology in oil and gas field development, etc. He is the principal investigator of 10+ research projects supported by the National Natural Science Foundation of China, the National Natural Science Foundation of Shandong Province, the Ministry of Education, and 10+ projects supported by oil companies in China. He has published more than 100 journal papers in the Chemical Engineering Journal, Water Resources Research, Fuel, and Journal of Geophysical Research-Solid Earth, and others. He has authorized 10+ Chinese patents and 3 American/Australia patents.
He teaches courses including Fluid Flow in Porous Media, Gas Reservoir Engineering, Reservoir Displacement Mechanism, and Introduction to Petroleum Industry etc.