Background: Drug-coated balloons have been used as a non-stenting treatment in coronary and peripheral artery disease. Until recently, only sirolimus- and paclitaxel-coated balloons have been investigated in clinical trials. We evaluated the safety and efficacy of an innovative everolimus-coated balloon (ECB) in a swine coronary artery model. Methods: thirty-two swine coronary arteries were prepared through dilatation with a non-coated angioplasty balloon in a closed-chest model. During a period of 90 days, the following four groups (four animals per group, two coronary arteries per animal) were compared for safety and efficacy: A, Rontis ECB with 2.5 μg/mm² of drug per balloon surface; B, Rontis ECB with 7.5 μg/mm²; C, Rontis Europa Ultra bare balloon; and D, Magic Touch, Concept Medical, sirolimus-coated balloon with a drug load of 1.3 μg/mm². Results: Differences in local biological effects (arterial reaction scores) and surface of intimal area (mm²) were not statistically significant between the treatment groups. Numerically, group A showed the lowest intimal area and intimal mean thickness, while group B showed the lowest stenosis among all groups. Conclusions: ECB was safe and effective in a porcine coronary artery model. The dose of everolimus may play a role in the biocompatibility of the balloon.

Chronic kidney disease (CKD) is on the rise, with sarcopenia accompanying CKD in an estimated 25% of patients, featuring as a potentially debilitating issue that should not be overlooked. Sarcopenia, characterized by a loss of skeletal muscle mass and strength, is multifactorial. The aging process, uremic toxins, systemic inflammation, oxidative stress, gut dysbiosis, hormonal dysregulation, dietary deficits, and even air pollution are among the major parameters being implicated in sarcopenia among patients with CKD. Additionally, the existence of various comorbidities, such as type 2 diabetes mellitus (T2DM), depression, and cardiovascular diseases (CVD), also contribute to the chronic low-grade inflammation associated with skeletal muscle inflammation and atrophy. The purpose of this review is to delve into the complex interplay of multiple factors being involved in the pathogenesis of sarcopenia in patients with CKD. Moreover, we aim to shed light upon nutritional aspects that could delay the development and progression of sarcopenia among patients with CKD. To address vitamin D deficiency, micronutrients and macronutrients together with physical activity remain the cornerstone of delaying the progression of sarcopenia in this sub-population. Additionally, experimental drugs exhibiting therapeutic potential are also being discussed. As sarcopenia and quality of life are interconnected, the timely recognition of sarcopenia, together with nutritional and therapeutic interventions, is of the utmost importance in our crusade for a better quality of life (QoL) in patients with CKD.

Dengue virus infection is a febrile illness caused by the Orthoflavivirus Dengue, which is transmitted by the mosquitoes Aedes aegypti or Aedes albopictus. Despite the fact that Dengue virus (DENV) is present in tropical and subtropical areas, climate change with global warming has been associated with the spread of Aedes aegypti and Aedes albopictus mosquitoes in several other regions worldwide. Notably, as the presence of Aedes albopictus has been confirmed in Southern Europe, already locally transmitted cases of Dengue virus infection have been reported in Europe. Apart from Europe, Australia has reported DENV cases in the 21st century that have been associated with the transmission of Aedes aegypti in the neighboring islands. Climate change, namely increasing temperatures, higher humidity and rainfalls, together with the development of urban heat islands, uncontrollable deforestation and urbanization, travelling and trade, has contributed significantly to the spread of DENV infection. Modern diagnosis based upon the advent of “multi-omics” techniques and machinery learning programs will be of the utmost importance for the early and accurate diagnosis of DENV infection. Finally, preventive measures for controlling Dengue virus infection, such as the use of repellents, educational programs, and improvement in water storage and waste management at the community levels would be very useful. Regarding climate change, the One Health Approach by integrating collaboration of various sectors and raising public awareness seems to be of the utmost importance in this context. Further investigations regarding the development of antiviral agents and vaccines will be an important asset in our armamentarium against DENV infection.