Luigi Lione

Dr. Luigi Lione

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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26 November 2023 in Medicina
Verified
Journal Article
Open access
PDF file
GCGiorgio Cannone
Giorgio Cannone
VVVincenzo Verzeletti
Vincenzo Verzeletti
ABAlberto Busetto
Alberto Busetto
LLLuigi Lione
Luigi Lione
ABAlessandro Bonis
Alessandro Bonis
FRFederico Rea
Federico Rea
Background and objectives: VATS segmentectomy has been proven to be effective in the treatment of stage I NSCLC, but its technical complexity remains one of the most challenging aspects for thoracic surgeons. Furthermore, 3D-CT reconstruction images can help in planning and performing surgical procedures. In this paper, we present our personal experience of 11 VATS anatomical resections performed after accurate pre-operative planning with 3D reconstructions. Materials and methods: A 3D virtual model of the lungs, airways, and vasculature was obtained, starting from a 1.25 mm 3-phase contrast CT scan, and the original images were used for the semi-automatic segmentation of the lung parenchyma, airways, and tumor. Results: Six males and five females were included in this study. The median diameter of the pulmonary lesion at the pre-operative chest CT scan was 20 mm. The surgical indication was confirmed in seven patients: in three cases, a lobectomy, instead of a segmentectomy, was needed due to intraoperative findings of nodal metastasis. Meanwhile, only in one case, we performed a lobectomy because of inadequate surgical resection margins. Skin-to-skin operative average time was 142 (IQR 1-3 105–182.5) min. The median post-operative stay was 6 (IQR 1-3 3.5–7) days. The mean value of the closest surgical margin was 13.7 mm. Conclusion: Image-guided reconstructions are a useful tool for surgeons to perform complex resections in order to spare healthy parenchyma and to ensure disease-free margins. Nevertheless, human skill and surgeon experience still remain fundamental for the final decisions regarding the proper resection to perform.

13 September 2023 in Surgeries
Verified
Journal Article
Open access
PDF file
VVVincenzo Verzeletti
Vincenzo Verzeletti
GCGiorgio Cannone
Giorgio Cannone
Lena HirtlerLena Hirtler
Lena Hirtler
ABAlessandro Bonis
Alessandro Bonis
AMAndrea Lloret Madrid
Andrea Lloret Madrid
FRFederico Rea
Federico Rea
The understanding of mediastinal anatomy represents a real challenge because of the vital structures inside it and due to its complex relationships with surrounding anatomical regions. Human anatomical specimens are always used both for the teaching of anatomy and the training of young surgeons, thus providing a deep understanding of the most complex anatomical regions and allowing less experienced surgeons to become familiar with surgical instruments and their use on actual human tissues. Despite the spread of these learning practices, there are no principles of dissection to follow for a young physician interested in the anatomy of the mediastinum. Therefore, the main objective of this study is to define a reliable and reproducible protocol for the dissection of the mediastinum. A stratigraphic anatomical dissection on three embalmed human specimens was performed. All steps were documented by high-quality photographs, taken with a professional digital reflex camera, and subsequently edited. A step-by-step anatomical dissection guide was created, detailing every phase, guiding the dissection of the mediastinal anatomy, and leading to the correct identification of its main anatomical structures. We present a step-by-step dissection guide to the mediastinal anatomy with point-by-point explanations and dedicated images, providing an additional tool for the comprehension of this complex anatomical area.

29 November 2024 in Complications
Verified
Journal Article
Open access
PDF file
LLLuigi Lione
Luigi Lione
ABAlberto Busetto
Alberto Busetto
ABAlessandro Bonis
Alessandro Bonis
VVVincenzo Verzeletti
Vincenzo Verzeletti
Eleonora FaccioliEleonora Faccioli
Eleonora Faccioli
FRFederico Rea
Federico Rea
Chylothorax is a rare complication occurring after cardio-thoracic surgical procedures. This condition presents challenges for diagnosis and treatment. Operative ductal ligation is the method of choice for relapsing or refractory cases, and it can be performed through the aid of IGC injection for the identification of chylous leakage. Our report presents the use of ICG fluorescence during VATS to successfully identify and treat a left-sided post-surgical chylothorax. The patient underwent a pulmonary wedge resection for a suspect malignant lesion and developed chylous leakage in the early postoperative period. On postoperative day 7, the patient underwent a revision thoracoscopy for hemostasis and thoracic duct ligation. ICG injections were performed through bilateral inguinal lymph nodes and approximately 15 min after we performed the re-thoracoscopy with effective identification and ligation of the chyle leakage. ICG fluorescence-guided VATS is a valuable and effective method for managing postoperative chylothorax, especially for left-sided leaks.

Verified
Journal Article
Open access
PDF file
LLLuigi Lione
Luigi Lione
ABAlberto Busetto
Alberto Busetto
VVVincenzo Verzeletti
Vincenzo Verzeletti
GCGiorgio Cannone
Giorgio Cannone
ABAlessandro Bonis
Alessandro Bonis
FRFederico Rea
Federico Rea
Background/Objectives: Chest X-ray (CXR) is currently the most used investigation for clinical follow-up after major noncardiac thoracic surgery. This study explores the use of lung ultrasound (LUS) as an alternative to CXR in the postoperative management of patients who undergo major thoracic procedures. Methods: The patients in our cohort were monitored with both a CXR and a lung ultrasonography after surgery and the day after chest drain removal. The LUS was performed by a member of the medical staff of our unit who was blinded to both the images and the radiologist’s report of the CXR. Findings were compared between the two methods. Results: In the immediate postoperative evaluation, 280 patients were compared, finding general agreement between the two procedures at 84% (kappa statistic, 0.603). The LUS showed a sensibility of 84.1%, a specificity of 84.3%, a positive predictive value (PPV) of 60.9%, and a negative predictive value (NPV) of 94.8%. We evaluated 219 out of 280 patients in the postdrainage-removal setting due to technical issues. Concordance between the methods in the postdrainage-removal setting was 89% (kappa statistic, 0.761) with the LUS demonstrating an 82.2% sensibility, a 93.2% specificity, a PPV of 85.7%, and an NPV of 91.3%. Conclusions: The results of this study showed a substantial agreement between LUS and CXR, suggesting that the LUS could reduce the number of X rays in certain conditions. The high NPV allows for the exclusion of PNX and pleural effusion without the need to expose patients to radiation. Discrepancies were noted in cases of mild pneumothorax or modest pleural effusion, without altering the clinical approach.

28 May 2024 in European Journal of Surgical Oncology
Verified
Journal Article
Closed access
ABAlessandro Bonis
Alessandro Bonis
VVVincenzo Verzeletti
Vincenzo Verzeletti
FLFrancesca Lunardi
Francesca Lunardi
LLLuigi Lione
Luigi Lione
GCGiorgio Cannone
Giorgio Cannone
FRFederico Rea
Federico Rea

2 July 2025 in Thoracic Cancer
Verified
Journal Article
Open access
ABAlberto Busetto
Alberto Busetto
GCGiorgio Cannone
Giorgio Cannone
LLLuigi Lione
Luigi Lione
ABAlessandro Bonis
Alessandro Bonis
VVVincenzo Verzeletti
Vincenzo Verzeletti
FRFederico Rea
Federico Rea