The large-scale and deep-layer deep neural network based on the Transformer model is very powerful in sequence tasks, but it is prone to overfitting for small-scale training data. Moreover, the prediction result of the model with a small disturbance input is significantly lower than that without disturbance. In this work, we propose a double consistency regularization (DOCR) method for the end-to-end model structure, which separately constrains the output of the encoder and decoder during the training process to alleviate the above problems. Specifically, on the basis of the cross-entropy loss function, we build the mean model by integrating the model parameters of the previous rounds and measure the consistency between the models by calculating the KL divergence between the features of the encoder output and the probability distribution of the decoder output of the mean model and the base model so as to impose regularization constraints on the solution space of the model. We conducted extensive experiments on machine translation tasks, and the results show that the BLEU score increased by 2.60 on average, demonstrating the effectiveness of DOCR in improving model performance and its complementary impacts with other regularization techniques.