Knee dislocations (KD) and multiligamentous knee injuries (MLKI) are challenging injuries to manage due to the high incidence of associated neurovascular compromise, extensive peri-articular soft-tissue trauma, and long-term functional deficits. Knee-spanning external fixation (KSEF) is occasionally utilized in the acute management of these injuries with the aim of maintaining alignment, protecting vascular repairs, allowing soft-tissue recovery prior to definitive treatment, and protecting freshly reconstructed or repaired ligaments. Despite its use in 5% of MLKIs and up to 50% of KDs, the clinical indications, outcomes, and complications associated with KSEF in the setting of KD/MLKI remain incompletely defined. Furthermore, KD/MLKI treatment algorithms incorporating decision-making related to KSEF application are limited both institutionally and within the literature. Thus, the purpose of this study was to consolidate the existing evidence related to the use of KSEF in the setting of KD/MLKI to support clinical decision-making and identify avenues for future investigation. Following a narrative review of the literature, the identified indications for KSEF in the setting of KD/MLKI were vascular injury, knee fracture-dislocation, extensive soft-tissue injury, persistent instability following reduction, open KDs, and when bracing is not feasible due to patient factors such as morbid obesity. Both rigid and hinged KSEF constructs have been described, with hinged fixators potentially permitting early motion while providing joint stability. Reported complications of KSEF include arthrofibrosis, infection, heterotopic ossification, and compartment syndrome, though available data are primarily retrospective and heterogeneous. Other topics that have been addressed in the literature include biomechanics, cost, magnetic resonance imaging (MRI) compatibility, and psychological impact. However, further research is needed to clarify its specific role, define standardized indications, and compare outcomes with non-invasive or alternative fixation and immobilization strategies. Plain Language Summary: Knee dislocations and multiple ligament knee injuries are serious injuries that can cause damage to blood vessels, nerves, and soft tissues around the knee, leading to long-term challenges with movement. Doctors sometimes use a device called a knee-spanning external fixator to treat these injuries, which is a metal frame that surgeons place outside of the leg to hold the knee stable This article summarizes what doctors and researchers currently know about knee-spanning external fixators, including their risks and benefits, and explains why more research is needed to guide treatment decisions related to the use of these devices in the management of severe knee injuries. This device is mainly used when the knee is too unstable for a brace, when there is a blood vessel injury, when the skin around the knee is severely damaged, and when the patient has multiple other injuries that need to be managed before their knee injury. While knee-spanning external fixators can help protect the knee and allow it to heal, they also carry several risks like stiffness, infections where the pins enter the skin, unwanted bone growth in the knee, and excessive pressure build-up within the leg. There are also psychological and cost-related concerns associated with the use of these devices. Despite being used frequently, doctors and researchers have not reached a clear agreement about exactly when to use or avoid these devices.