Inefficient soil management is a hindrance to food productivity and a contributing factor to the degradation of soil quality. Despite decades of research confirming the benefits of using sensors in effective soil management and crop yield, they are still not widely used in farms for several reasons including high cost, difficulty in large area deployment, and requirement of labor-intensive wiring. In this paper, we report a low-cost battery-less chipless wireless sensor tag that can be batch-manufactured for large-scale agricultural surveillance. The sensor tag works based on backscattering techniques for the wireless measurements of the volumetric water content (VWC) of the soil. The sensor tag consists of shorted dipole resonators whose resonance frequencies are dependent on the effective permittivity of the VWC of its surrounding soil. The resonant frequency of the sensor tag is measured by an orthogonally polarized reader antenna that observes the peak in the backscattered spectrum. As a proof-of-concept, a sensor tag with two resonators of length 10 cm and 9 cm, is buried at a depth of 10 cm in the soil and is wirelessly read from a free-space distance of 50 cm, to demonstrate its capability to measure the changes in VWC. The resonators of length 10 cm and 9 cm have demonstrated a linear change of -3.92 MHz/VWC and -4.85 MHz/VWC, respectively, within the VWC range 4-27%. By changing the functional passivation layers on the demonstrated sensor tag, this concept can be applied to a wide range of low-cost subsoil sensors for precision agriculture applications.
Inflammatory bowel disease (IBD) has become alarmingly prevalent in the last two decades affecting 6.8 million people worldwide with a starkly high relapse rate of 40% within 1 year of remission. Existing visual endoscopy techniques rely on subjective assessment of images that are error-prone and insufficient indicators of early-stage IBD, rendering them unsuitable for frequent and quantitative monitoring of gastrointestinal health necessary for detecting regular relapses in IBD patients. To address these limitations, we have implemented a miniaturized smart capsule (2.2 cm × 11 mm) that allows monitoring reactive oxygen species (ROS) levels as a biomarker of inflammation for quantitative and frequent profiling of inflammatory lesions throughout the gastrointestinal tract. The capsule is composed of a pH and oxidation reduction potential (ORP) sensor to track the capsule’s location and ROS levels throughout the gastrointestinal tract, respectively, and an optimized electronic interface for wireless sensing and data communication. The designed sensors provided a linear and stable performance within the physiologically relevant range of the GI tract (pH: 1–8 and ORP: −500 to +500 mV). Additionally, systematic design optimization of the wireless interface electronics offered an efficient sampling rate of 10 ms for long-running measurements up to 48 h for a complete evaluation of the entire gastrointestinal tract. As a proof-of-concept, the capsule the capsule’s performance in detecting inflammation risks was validated by conducting tests on in vitro cell culture conditions, simulating healthy and inflamed gut-like environments. The capsule presented here achieves a new milestone in addressing the emerging need for smart ingestible electronics for better diagnosis and treatment of digestive diseases.
14 December 2023 in IEEE Transactions on Biomedical Engineering
Effective management of Inflammatory Bowel Disease (IBD) is contingent upon frequent monitoring of inflammation levels at targeted locations within the gastrointestinal (GI) tract. This is crucial for assessing disease progression and detecting potential relapses. To address this need, a novel single-use capsule technology has been devised that enables region-specific inflammation measurement, thereby facilitating repeatable monitoring within the GI tract. The capsule integrates a pH-responsive coating for location-specific activation, a chemiluminescent paper-based myeloperoxidase (MPO) sensor for inflammation detection, and a miniaturized photodetector, complemented by embedded electronics for real-time wireless data transmission. Demonstrating linear sensitivity within the physiological MPO concentration range, the sensor is capable of effectively identifying inflammation risk in the GI fluid. Luminescence emitted by the sensor, proportional to MPO concentration, is converted into an electrical signal by the photodetector, generating a quantifiable energy output with a sensitivity of 6.14 µJ/U.ml −1 . The capsule was also tested with GI fluids collected from pig models simulating various inflammation states. Despite the physiological complexities, the capsule consistently activated in the intended region and accurately detected MPO levels with less than a 5% variation between readings in GI fluid and a PBS solution. This study heralds a significant step towards minimally invasive, in situ GI inflammation monitoring, potentially revolutionizing personalized IBD management and patient-specific therapeutic strategies.
The development of flexible hybrid electronics (FHEs) with high‐throughput integration of electrical components onto digitally printed circuits has a wide range of applications, such as asset tracking, wearable electronics, and structural health monitoring. However, one of the major challenges with FHEs is the process of soldering the electrical components onto a printed circuit while having minimal thermal damage to the printed traces and their temperature‐sensitive polymeric substrates. Here, the possibility of utilizing near‐infrared (NIR) technology as a nondestructive photonic approach for rapid soldering and mounting electrical components onto printed circuits while keeping the polymer substrate at a relatively low temperature during the soldering process is investigated. Results of this systematic study show that FHEs prepared with the optimized NIR processing conditions produce the desired reflow of solder with effective electrical connection and metallic bonding of electrical components onto the conductive traces with excellent mechanical stability (no failure even after 1000 cycles of bending). Furthermore, using this technique and as a proof of concept, the fabrication of a wearable FHE device that provides a remote assessment of the wound exudate absorption in dressings and notifies caregivers of the appropriate time to change the dressing is demonstrated.
9 February 2024 in IEEE Transactions on Biomedical Engineering
A substantial number of critically ill patients in intensive care units (ICUs) rely on indwelling urinary catheters (IDCs), demanding regular monitoring of urine bags. This process increases the workload for healthcare providers and elevates the risk of exposure to contagious diseases. Moreover, IDCs are a primary cause of catheter-associated urinary tract infections (UTIs) in ICU patients whose delayed detection can have life-threatening complications. To address this, we have developed a Sticker Type Antenna for Remote Sensing (STARS) system capable of measuring urine flow rate and conductivity as early-risk markers for UTIs, alongside tracking patients’ urine bag status to facilitate medical automation for healthcare providers. STARS comprises a simple, low-cost, disposable antenna module for contactless measurements of urine volume and conductivity, and a reusable wireless module for real-time data transmission. Systematic studies on STARS revealed its stable performance within physiologically relevant ranges of urine volume (0 to 2000 ml) and conductivity (5 to 40 mS/cm) in urine bags. As a proof-of-concept, STARS was tested in artificially created healthy and infected urine specimens to validate its non-contact sensing performance in detecting the onset of UTIs in catheterized patients within a hospital-like environment. STARS represents the first application of a real-time, contactless, wireless monitoring platform for simultaneous urine bag management and early risk detection of UTIs.
22 August 2017 in Journal of Micromechanics and Microengineering
RF MEMS capacitive shunt switches with a dielectric-on-metal (DOM) capacitor, which are widely used for microwave applications in the communication field, suffer from some serious drawbacks. A significant shift is observed in the resonant frequency of these switches due to the reduction in the down-state capacitance caused by the surface roughness of the dielectric layer. In order to achieve accurate down-state capacitance, a thin layer of floating metal is deposited on the dielectric layer converting the DOM switch to a metal-insulator metal (MIM) switch. The MIM switch opens up interesting possibilities in the design, such as achieving flexibility in the operating frequency of the switch. This paper reports a novel method to achieve design flexibility for multi-frequency operation in switches, by effectively utilizing the equipotential nature of the floating metal in the MIM capacitor. Unlike in a DOM switch, the resonant frequency can be varied by changing merely the length of the floating metal, without having to make any other structural modifications. This enables to have switches operating at different frequency on the same wafer. The beams of the switches are also designed in such a way as to provide stress resilience, thereby preventing buckling. This paper presents the design, simulation, fabrication and characterization of a switch that operates in the X-band. The fabricated switches show excellent stress resilience. The characterized switch demonstrates a reduction in the resonant frequency in proportion to an increase in the length of the floating metal, hence validating the design flexibility proposed in this paper.