Despite extensive research, there is currently no specific biomarker that reliably and universally indicates treatment response in psoriasis. Multiple studies have evaluated systemic inflammation markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic immune response index (SIRI) in psoriasis patients. However, there are limited studies investigating changes in these markers with biologic therapy. The goal of this study was to investigate the impact of biologic therapy on parameters including NLR, PLR, MLR, SII, and SIRI in patients with psoriasis. In this cohort study, we retrospectively evaluated 108 psoriasis patients who were on biological treatment, including interleukin (IL)17, IL23, and IL12/23 inhibitors, for a minimum of 12 weeks. We analyzed Psoriasis Area Severity Index (PASI) scores, complete blood count parameters, and C-reactive protein (CRP) levels both before and after 12 weeks of treatment. The NLR, PLR, MLR, SII, SIRI, and CRP values all demonstrated a significant decrease, regardless of the specific type of biologic agent (p=0.001, 0.007, 0.011, <0.001, <0.001 and <0.001, respectively). Furthermore, we observed a statistically significant but low correlation between the reduction in PASI scores and PLR, SII, and SIRI values (p=0.036, r=0.202; p=0.042, r=0.196; p=0.023, r=0.219, respectively). The NLR, MLR, especially PLR, SII, and SIRI might be used as simple, convenient, and inexpensive laboratory markers to monitor the degree of inflammation and response to treatment after biologic therapy in daily practice.

We aimed to detect the frequency of fibromyalgia syndrome in patients with rosacea and determine whether this frequency was affected by the severity of rosacea and the quality of life.

Background: Investigating psoriasis patients’ enthesopathy and peripheral neuropathy, which dermatologists often neglect.Methods: Seventy-four psoriasis patients’ lower limb entheses were evaluated by ultrasonography using Glasgow Ultrasound Enthesitis Scoring Scale (GUESS). Sensory and motor nerve conduction studies in median and ulnar nerve, motor nerve conduction research of peroneal and tibial nerves and sensory conduction study on right sural nerve was performed in 25 patients.Results: 172 of 730 entheses had ultrasonographic enthesopathy symptoms (23.56%). Enthesopathy was substantially more common in cases involving the nail (p = 0.004). The frequency of enthesopathy did not change significantly between symptomatic and asymptomatic patients (p = 0.408). Seven of 25 patients (28%) had a pathology in nerve conduction studies. With increasing GUESS scores, bilateral ulnar and right tibial nerve distal motor latencies were shown to become longer (p = 0.001, p = 0.01, p =0.019), although left ulnar nerve sensory conduction velocity got slower (p = 0.033).Conclusions: Enthesopathy and peripheral nerve dysfunction were frequently observed in psoriasis patients. Dermatologists should be mindful of neuromusculoskeletal disorders in psoriasis patients.