Although several clinical manifestations of persistent long coronavirus disease (COVID-19) have been documented, their effects on the cardiovascular and autonomic nervous system over the long term remain unclear. Thus, we examined the presence of alterations in cardiac autonomic functioning in individuals with long-term manifestations. The study was conducted from October 2020 to May 2021, and an autonomic assessment was performed to collect heart rate data for the heart rate variability (HRV) analysis. The study participants were divided into the long COVID clinical group, the intragroup, which included patients who were hospitalized, and those who were not hospitalized and were symptomatic for different periods (≤3, >3, ≤6, and >6 months), with and without dyspnoea. The control group, the intergroup, comprised of COVID-free individuals. Our results demonstrated that the long COVID clinical group showed reduced HRV compared with the COVID-19-uninfected control group. Patients aged 23–59 years developed COVID symptoms within 30 days after infection, whose diagnosis was confirmed by serologic or reverse-transcription polymerase chain reaction (swab) tests, were included in the study. A total of 155 patients with long COVID [95 women (61.29%), mean age 43.88 ± 10.88 years and 60 men (38.71%), mean age 43.93 ± 10.11 years] and 94 controls [61 women (64.89%), mean age 40.83 ± 6.31 and 33 men (35.11%), mean age 40.69 ± 6.35 years] were included. The intragroup and intergroup comparisons revealed a reduction in global HRV, increased sympathetic modulation influence, and a decrease in parasympathetic modulation in long COVID. The intragroup showed normal sympathovagal balance, while the intergroup showed reduced sympathovagal balance. Our findings indicate that long COVID leads to sympathetic excitation influence and parasympathetic reduction. The excitation can increase the heart rate and blood pressure and predispose to cardiovascular complications. Short-term HRV analysis showed good reproducibility to verify the cardiac autonomic involvement.

Long COVID is characterized by persistent signs and symptoms that continue or develop for more than 4 weeks after acute COVID-19 infection. Patients with Long COVID experience a cardiovascular autonomic imbalance known as dysautonomia. However, the underlying autonomic pathophysiological mechanisms behind this remain unclear. Current hypotheses include neurotropism, cytokine storms, and inflammatory persistence. Certain immunological factors indicate autoimmune dysfunction, which can be used to identify patients at a higher risk of Long COVID. Heart rate variability can indicate autonomic imbalances in individuals suffering from Long COVID, and measurement is a non-invasive and low-cost method for assessing cardiovascular autonomic modulation. Additionally, biochemical inflammatory markers are used for diagnosing and monitoring Long COVID. These inflammatory markers can be used to improve the understanding of the mechanisms driving the inflammatory response and its effects on the sympathetic and parasympathetic pathways of the autonomic nervous system. Autonomic imbalances in patients with Long COVID may result in lower heart rate variability, impaired vagal activity, and substantial sympathovagal imbalance. New research on this subject must be encouraged to enhance the understanding of the long-term risks that cardiovascular autonomic imbalances can cause in individuals with Long COVID.

ASSOBRAFIR Ciência, vol.12, p.0-0, 2021

Introdução: O vírus da Imunodeficiência Humana é um lentivírus que deprime o sistema imunológico, favorecendo o desencadeamento de déficits, incluindo no sistema motor. Esses déficits podem ser gerados através de efeitos adversos da terapia antirretroviral. Objetivos: Descrever o perfil da coordenação motora de crianças e adolescentes infectadas por via vertical pelo vírus da Imunodeficiência Humana e expostas ao uso de terapias antirretrovirais. Materiais e Métodos: Estudo do tipo observacional e transversal, onde foram avaliadas 34 crianças e adolescentes matriculadas na Unidade de Referência Materno Infantil e Adolescente do Pará e distribuídas em dois grupos: 1) Grupo Controle: n=13, com sorologia negativa para o vírus da imunodeficiência humana, porém expostos a medicação no pré, peri ou pós-natal; 2) Grupo Experimental: n=21, crianças com sorologia positiva para o HIV e exposição prolongada as terapias antirretrovirais há mais de 1 ano. Foi utilizada a bateria de teste Korperkoordination test fur Kinder para análise do desempenho motor. A análise estatística foi realizada pelo software Bioestat® 5.0, considerando nível de significância de 5%. Resultados: Identificou-se no grupo experimental déficit na coordenação motora para tarefas de equilíbrio (p=0,003) e lateralização (p=0,007) comprometendo a conscientização corporal. A análise do quociente motor global e deste com relação a idade cronológica também apresentaram significância, respectivamente p=0,027 e p=0,003. Conclusão: Crianças e adolescentes infectadas por via vertical pelo vírus da Imunodeficiência Humana e expostas ao uso prolongado da terapia antirretroviral apresentaram comprometimento do desempenho motor para as tarefas de equilíbrio e lateralidade.