Hypertension is defined as a systolic blood pressure (SBP) of over 140 mmHg or diastolic blood pressure (DBP) of over 90 mmHg. Hypertension is widely known to be a factor affecting human health, so its prevention is considered important. We investigated the effect of casein-derived tripeptide Met-Lys-Pro (MKP) on blood pressure in a randomized, placebo-controlled, parallel-group study. Participants were healthy adults with SBP between 120 and 139 mmHg, and/or DBP between 80 and 89 mmHg. A total of 121 participants were randomly assigned to the MKP group or placebo group. Participants received either a test powder containing 100 μg of MKP or a placebo powder without MKP for 12 weeks. As a result, SBP and DBP were significantly lower in the MKP group than in the placebo group. No adverse events associated with the MKP intake were observed. This study showed that MKP has a beneficial effect on lowering blood pressure in healthy adults with high-normal and elevated blood pressure and can be safely used for continuous intake.

Elevated serum uric acid (SUA) levels are associated with several diseases. Whey protein hydrolysate (WPH: product name, MWPH) contains multiple bioactive peptides and exhibits xanthine oxidase inhibitory activity in vitro. This randomized, parallel group, placebo‐controlled study evaluates WPH supplementation on SUA levels in adult men with fasting SUA levels of 6.0–7.9 mg/dL. Participants consumed 5.0 g of WPH or a placebo daily for 12 weeks. The primary endpoint, SUA, was significantly reduced in the WPH group compared to the placebo group after 12 weeks ( p = 0.004). Furthermore, WPH also contains peptides that inhibit fat accumulation in cells in vitro, and in this study, BMI was significantly reduced in the WPH group compared to the placebo group after 12 weeks ( p = 0.002). In a healthy subgroup of participants not receiving drug therapy, WPH also improved serum creatinine ( p = 0.009) and estimated glomerular filtration rate ( p = 0.010), indicating potential renal benefits. No serious adverse events or side effects were observed throughout the trial. The findings indicate that WPH supplementation can effectively lower SUA levels and improve renal function, offering a promising dietary intervention to manage hyperuricemia and associated metabolic conditions.