1. Pharmacogenomics and Pharmacogenetics of Antipsychotics We are working on screening biomarkers for personalized responses to antipsychotics (APDs) in patients with server psychiatric disorders, including both drug response and drug induced side-effects. Our approach integrates population-based association analysis with multi-omics functional studies to uncover critical insights. 2. Molecular Diagnostics We are deeply interested in innovative technologies and systems for personalized medicine. To advance precision medicine applications, we have developed several novel methods, including CRISPR/Cas9-based detection of low-frequency gene mutations and a rapid multi-fragment DNA ligation system.