Giorgio Graziano

Giorgio Graziano

orcid

Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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12 April 2021 in European Journal of Trauma and Emergency Surgery
Verified
Journal Article
Open access
PDF file
MCMarco Ceresoli
Marco Ceresoli
FCFederico Coccolini
Federico Coccolini
SMStefano Magnone
Stefano Magnone
ALAlessandro Lucianetti
Alessandro Lucianetti
PBPietro Bisagni
Pietro Bisagni
PFPaola Fugazzola
Paola Fugazzola
Background: During pandemic, admissions for surgical emergencies dropped down dramatically. Also acute appendicitis decreased. The aim of the present study was to evaluate the change in volume and clinical presentation of patients with acute appendicitis during pandemic and the variation in treatment. Methods: This is a retrospective study of patients admitted in 11 Italian hospital for acute appendicitis during the lockdown period (March–April 2020) compared with the same period of the previous 2 years (2018–2019). The number and the rate of complicated and non-complicated acute appendicitis were recorded and compared between the two study periods; non-operative vs operative treatment and negative appendectomy rate were also recorded. Results: The study included 532 patients, 112 in the study period and 420 in the control period; Hospital admission for acute appendicitis dropped by 46% (OR 0.516 95% CI 0.411–0.648 p < 0.001) during the 2020 lockdown. The number of complicated acute appendicitis did not change (− 18%, OR 0.763 95% CI 0.517–1.124 p = 0.1719), whereas the number of non-complicated acute appendicitis significantly decreased (− 56%, OR 0.424 95% CI 0.319–0.564 p < 0.001). Non-operative treatment rate remained similar (12.1% vs. 11.6% p = 0.434). The negative appendectomy rate also significantly decreased (6.1% vs. 17.3%, p = 0.006). Conclusions: The present study found a significant reduction of both admissions for non-complicated acute appendicitis and negative appendectomy rate during the pandemic period. Conversely, admissions for complicated acute appendicitis did not change. Trial registration: NCT04649996.

17 September 2020 in Colorectal Disease
Verified
Journal Article
Open access
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GGGiorgio Graziano
Giorgio Graziano
Aim: Crohn's disease (CD) requires a multidisciplinary approach and surgery should be undertaken by dedicated colorectal surgeons with audited outcomes. We present a national, multicentre study, with the aim to collect benchmark data on key performance indicators in CD surgery, to highlight areas where standards of CD surgery excel and to facilitate targeted quality improvement where indicated.Methods: All patients undergoing ileocaecal or redo ileocolic resection in the participating centres for primary and recurrent CD from June 2018 to May 2019 were included. The main objective was to collect national data on hospital volume and practice variations. Postoperative morbidity was the primary outcome. Laparoscopic surgery and stoma rate were the secondary outcomes.Results: In all, 715 patients were included: 457 primary CD and 258 recurrent CD with a postoperative morbidity of 21.6% and 34.7%, respectively. Laparoscopy was used in 83.8% of primary CD compared to 31% of recurrent CD. Twenty‐five hospitals participated and the total number of patients per hospital ranged from 2 to 169. Hospitals performing more than 10 primary CD procedures per year showed a higher adoption of laparoscopy and bowel sparing surgery.Conclusions: There is significant heterogeneity in the number of CD surgeries performed per year nationally in Italy. Our data suggest that high‐volume hospitals perform more complex procedures, with a higher adoption of bowel sparing surgery. The rate of laparoscopy in high‐volume hospitals is higher for primary CD but not for recurrent CD compared with low‐volume hospitals.

6 January 2021 in Updates in Surgery
Verified
Journal Article
Closed access
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VCValerio Celentano
Valerio Celentano
GPGianluca Pellino
Gianluca Pellino
ASAntonino Spinelli
Antonino Spinelli
FSFrancesco Selvaggi
Francesco Selvaggi
SCSICCR Current status of Crohn’s disease surgery collaborative
SICCR Current status of Crohn’s disease surgery collaborative
OSOn Behalf Of The Italian Society Of Colorectal Surgery Siccr
On Behalf Of The Italian Society Of Colorectal Surgery Siccr

23 May 2022 in International Journal of Colorectal Disease
Verified
Journal Article
Open access
PDF file
VCValerio Celentano
Valerio Celentano
GGGiorgio Graziano
Giorgio Graziano
GPGianluca Pellino
Gianluca Pellino
MRMatteo Rottoli
Matteo Rottoli
GSGianluca Sampietro
Gianluca Sampietro
FSFrancesco Selvaggi
Francesco Selvaggi
Introduction: Intra-abdominal abscesses complicating Crohn’s disease (CD) present an additional challenge as their presence can contraindicate immunosuppressive treatment whilst emergency surgery is associated with high stoma rate and complications. Treatment options include a conservative approach, percutaneous drainage, and surgical intervention. The current multicentre study audited the short-term outcomes of patients who underwent preoperative radiological drainage of intra-abdominal abscesses up to 6 weeks prior to surgery for ileocolonic CD. Methods: This is a retrospective, multicentre, observational study promoted by the Italian Society of Colorectal Surgery (SICCR), including all adults undergoing ileocolic resection for primary or recurrent CD from June 2018 to May 2019. The outcomes of patients who underwent radiological guided drainage prior to ileocolonic resection were compared to the patients who did not require preoperative drainage. Postoperative morbidity within 30 days of surgery was the primary endpoint. Postoperative length of hospital stay (LOS) and anastomotic leak rate were the secondary outcomes. Results: Amongst a group of 575 included patients who had an ileocolic resection for CD, there were 36 patients (6.2%) who underwent abscess drainage prior to surgery. Postoperative morbidity (44.4%) and anastomotic leak (11.1%) were significantly higher in the group of patients who underwent preoperative drainage. Conclusions: Patients with Crohn’s disease who require preoperative radiological guided drainage of intra-abdominal abscesses are at increased risk of postoperative morbidity and septic complications following ileocaecal or re-do ileocolic resection.

28 February 2022 in HPB
Verified
Journal Article
Closed access
SFSimone Famularo
Simone Famularo
NRNadia Russolillo
Nadia Russolillo
Matteo DonadonMatteo Donadon
Matteo Donadon
FCFederica Cipriani
Federica Cipriani
Francesco ArditoFrancesco Ardito
Francesco Ardito
DGDavide Gaudesi
Davide Gaudesi

4 October 2023 in Medicina
Verified
Journal Article
Open access
PDF file
FSFrancesca De Stefano
Francesca De Stefano
GGGiorgio Graziano
Giorgio Graziano
JVJacopo Vigano'
Jacopo Vigano'
AMAurelio Mauro
Aurelio Mauro
APAndrea Peloso
Andrea Peloso
LALuca Ansaloni
Luca Ansaloni
Gastritis cystica profunda (GCP) has been defined as a rare submucosal benign gastric lesion with cystic gland growth. Due to its unclear etiopathogenesis, this lesion is often misdiagnosed and mistaken for other gastric masses. Currently, a standardized treatment for GCP lesions is still missing. Here, we illustrate a case of a patient admitted to our general surgery department for melena and general discomfort. No history of peptic ulcer or gastric surgery was present. Upper GI endoscopy was performed, showing a distal gastric lesion with a small ulceration on the top. CT-scan and endoscopic ultrasound confirmed the presence of the lesion, compatible with a gastric stromal tumor, without showing any eventual metastasis. Surgical gastric resection was performed. Histological findings were diagnostic for GCP, with cistically ectasic submucosal glands, chronic inflammation, eosinophilic infiltration and foveal hyperplasia. GCP is a very exceptional cause of upper-GI bleeding with specific histological features. Its diagnosis as well as its therapy are challenging, resulting in several pitfalls. Even though it is a rare entity, GCP should always be considered in the differential diagnosis of gastric submucosal lesions.