The water inrush from karst collapse column (KCC) is a cascading, vicious cycle disaster caused by geological and mining activities, that can cause serious casualties and property losses. The key to preventing this risk is to study the mechanism of water inrush under confining pressure. Aiming at the investigationg the characteristics of the KCC named X1 in Chensilou mine, a series of methods, including connectivity experiments, water pressure monitoring tests in two side-walls, and numerical simulations based on plastic damage-seepage (PD-S) theory have been developed. The methods are used to test the security of the 2519 mining area, the damage thickness, pore water pressure, and seepage vector in the X1. The results indicate that the X1 has a certain water blocking capacity. In addition, with the decrease of confining pressure and increase of shear stress, deviatoric stress could cause the increase of permeability, the reduction of strength, and the reduction of pore water pressure in KCC. Therefore the increased effective stress in the rock will force the rock to become more fractured. Conversely, the broken rock could cause the change of stress, and further initiate new plastic strains, damage and pore water pressure until a new equilibrium is reached. This cascading water inrush mechanism will contribute to the exploitation of deep coal resources in complex geological and hydrogeological conditions.

The mining of shallow buried and thick coal seams may cause ground settlement, loss of surface water, and even soil desertification in arid–semi-arid climate zones. The key to protecting surface water resources through the technology of separated strata grouting is to study the evolution of the separation space under the key stratum (KS) with the change of strata. Aiming at the section of underground strata characteristics of F6202 and F6208 working faces, similar simulation tests under three typical geological conditions were carried out. Based on the experimental results, a theoretical calculation model was established, and the practice of separation grouting was carried out. The results show that, under the conditions of a thick coal seam with one KS, the structure formed by breaking strata below the KS was relatively unstable, and the separation space was relatively large, which is likely to cause serious ground settlement. More seriously, with the increase of the weakly consolidated layer and coal seam thickness, the increase of the ratio of rock to soil in the weakly consolidated layer, and the decrease of the thickness of the strata below the KS (two KS condition), the separation space was further increased. Based on the above analysis, combined with the real-time feedback data of the grout amount and pressure on hydraulic support, the position of the grouting borehole was determined, and the speed of mining advance was adjusted in time, thus effectively controlling the curvature of the ground settlement, protecting the integrity of the red clay layer near the surface, and consequently protecting water resources.