Suppositories are an underutilized dosage form. Suppositories are such types of dosage forms used to provide medication via the vaginal and rectal routes. Vaginal suppositories are commonly referred to as pessaries. It was developed from a formulation called Liquid Enema. Enema has a great disadvantage in that, it used to leak out of the cavity in which they were put. So, this led to the discovery of suppositories as an alternative method of medication. Suppositories can be described as semi-solid dose forms utilized to provide medications for therapeutic action via rectal, vaginal, or urethral routes, where they will melt or dissolve and deliver localized or systemic impact. It is composed of cocoa butter, PEG, and fatty base (and a few others) as main ingredients, and it comes in different shapes and sizes. Although suppositories were formulated it was not that stable inside the orifices and also used to draw out of it. So, in order to overcome the problem of leaking, researchers added some mucoadhesive substance to improve its stability. From here onward improvement in the suppositories started as an alternative medication other than oral dosage form. The current article aimed to fabricate descriptive information about the advancement of suppositories. These advancements are Bi-layered Suppositories, Homogeneous Plain Suppositories, Hollow Suppositories, Effervescent Suppositories, Gel suppositories, Sustained Release Suppositories, etc.

The concept of novel drug delivery with the comparison of modern and conventional delivery system. The Ocular is the most challenging organ to deliver drugs after the brain and conventional delivery systems currently available in the arsenal have severe limitations thus there is a strong demand for an improved ocular delivery system and a suitable opinion is a novel drug delivery system. Noisome and liposome are dominant vesicular carriers in ocular drug delivery, as both systems improve the bioavailability of drugs and are well tolerated in ocular; however, both delivery systems have critical drawbacks of physicochemical stability during storage, lacking contain in dispersion and fusion of nanoparticles. The gel form is formulated by the coacervation phase’s parathion method. The material utilized for the formulation of proniosomes are non-ionic surfactant, cholesterol, carrier and alcohol are well tolerable and nontoxic in the ocular. The benefits offered to ocular drug delivery are prolonged retention time of formulation on the ocular surface, enhance ocular penetration to deliver effective therapeutic dosage, improve bioavailability of hydrophobic, lipophilic and herbal drugs, biocompatible, biodegradable, nontoxic and stable stored in pro-vesicle state. Hereby article will review proniosomes drug delivery from the perspective of ophthalmic delivery, discussing proniosomes as an ocular carrier, materials and methods their effect on ocular drug delivery and depth explanation of recent studies of proniosome in the ocular. Proniosomes are one of the sterile drug delivery systems that have seen a tremendous increase in popularity and are heavily utilized in cancer therapy. Researchers and academicians generally agree that incorporating the medicine into niosomes will improve its ability to target tissues where it is needed. Proniosomes created by academics and researchers. Niosomes that are produced from protostomes are a promising medication delivery system. They are well known for avoiding several issues related to aqueous noisome dispersion as well as issues with physical stability such aggregation, fusion, and leakage. They make transportation, distribution, storage, and dosage even more convenient. Proniosomes not only present a promising medication delivery method but also have the potential to speed up the skin barrier's repair.

Since hypertension raises the risk of cardiovascular disease and other consequences, it must be considered when deciding on a patient's course of treatment. Hypertension is the most dangerous adverse effect of corticosteroid use. Corticosteroid treatments, generally known as steroids or anti-inflammatory pharmaceuticals, are used to treat a variety of diseases. They differ from anabolic steroids, which some people often use illicitly to gain muscular mass. Despite being essential in the care of many inflammatory and immunologic illnesses, systemic corticosteroids carry a number of hazards. Osteoporosis, adrenal suppression, hyperglycemia, dyslipidemia, cardiovascular disease, Cushing's syndrome, psychiatric disorders, and immunosuppression are some of the more severe adverse effects of systemic corticosteroid therapy, particularly when taken in high dosages for lengthy periods of time. Using the most recent data as well as the authors' clinical expertise, this extensive study discusses these adverse occurrences and offers helpful advice for their prevention and management.