Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effect. The aim of this review was to explore the literature and report the antineoplastic effect of heparin and derivatives on CRC. MEDLINE and EMBASE databases were searched for relevant articles. Nineteen studies were included (n = 19). Fifteen were lab studies conducted in vivo or in vitro on CRC cell lines and/or mice (n = 15). Four were in vivo clinical studies (n = 4). CRC tumor growth was reduced by 78% in one study, (p < 0.01), while tumorigenesis was suppressed in heparin-treated mice in seven studies. A high dose of low molecular weight heparin for extended duration significantly reduced post-operative VEGF, suggesting that such a regime may inhibit tumor angiogenesis and distant metastasis. A randomized trial demonstrated the antineoplastic effect of nadroparin as the 6 month survival in palliative patients increased. Another study has reported that disease-free survival of CRC patients was not affected by a similar tinzaparin regime. The anti-cancer properties of heparin and derivatives are promising, especially in lab studies. Further clinical trials are needed to investigate the anti-cancer benefit of heparin on CRC.

Reconstructive microsurgery remains a demanding field, requiring technical expertise and long operating hours. This places microsurgeons at increased risk of dissatisfaction and burnout. The co-surgeon model has been developed to mitigate these challenges. This study was designed to evaluate microsurgeon perspectives on the characteristics and impact of the co-surgeon model for microsurgical free flaps.An electronic anonymous survey was distributed via email to attending microsurgeon members of the American Society of Reconstructive Microsurgeons. The survey collected various demographic and practice-related information including Likert scale questions to assess microsurgeon perspectives on the utility of the co-surgeon model.A total of 862 microsurgeons received the survey, with 102 responses available for analysis. The average age of respondents was 46.6 (± 9.7) years. Most of the microsurgeons were male (71%) practicing in the United States (93%), with 74.5% of respondents utilizing a co-surgeon model in their practice. Bilateral breast flaps were the most common microsurgical procedure performed using a co-surgeon (85%), followed by head and neck free flaps (60%), with immediate lymphatic reconstruction being the least common (3.1%). On the day of the co-surgery case, the co-surgeon was more likely than the primary surgeon to have additional cases (68.4 and 36.4%, respectively), with the additional cases being rarely free flaps. More than 80% of microsurgeons stated that the co-surgeon model improves “very much” or “quite a bit” operative efficiency and duration, as well as surgeon well-being and career longevity.This study provides new insight into the utility of using a co-surgeon for free flap reconstruction by demonstrating that approximately 80% of microsurgeons have a positive perception of the model's impact on procedure efficiency, operative time, surgeon well-being, and career longevity. Therefore, adopting a co-surgeon model for microsurgical free flap reconstruction may be useful in reducing burnout and promoting well-being among microsurgeons.

The demand for breast reconstruction has increased owing to the established benefits for patients. Given the long-term survivorship, objective data are vital to aid patients in making treatment decisions. This prospective longitudinal observational study was carried out to objectively quantify the impact of simple mastectomy (Mx), implant-based reconstruction (IBR) and deep inferior epigastric perforator (DIEP) on upper limb (UL) activity using wearable activity monitors (WAMs). Forty-eight consecutive patients who underwent breast and reconstructive surgery were identified from operating schedules. Recruited participants were invited to wear WAMs on both wrists for an average of 3 days preoperatively, for 2 weeks post-operatively and more than 6 months post-operatively. A significantly greater reduction in gross physical activity as a percentage of preoperative activity was observed in DIEP compared with Mx and IBR patients across week 1 (median: 40% versus 62% versus 62%; p<0.001) and week 2 (median: 60% versus 77% versus 84%; p<0.001). In the long-term follow-up, the average activity had reached or exceeded their baseline levels for all operative procedures, Mx=114%, IBR=98% and DIEP=103%. DIEP was an independent predictor of recovery in weeks 1 (F=4.796, p=0.043) and 2 (F=7.306, p=0.015). Despite DIEP patients having the lowest UL activity level in the acute post-operative period when compared with Mx and IBR patients, average activity levels returned to baseline in the long-term for all procedures. Objective monitoring of recovery using WAMs can support the development of a personalised rehabilitation programme for those at risk of developing complications.

Glenoid loosening remains a concern in anatomical total shoulder replacement. Preoperative planning software allows optimization of the component positioning, but the target orientation remains unclear due to conflicting optimization priorities. Commonly, the component is aligned to the prescribed version and inclination that reflect the population's average anatomy. The freehand technique attempts to secure strong fixation by aiming to preserve the subchondral bone. This study compared the state of the subchondral plate after reaming and compared the results of these two techniques. Two groups of shoulder computed tomography scans were assessed, 34 normal and 34 osteoarthritic. Preoperative planning software was used to place the glenoid component in prescribed adjusted angles, with neutral (0^o,0^o), retroverted (-10^o,0^o) and inclined alignment (0^o,10^o). The computed tomography Hounsfield values at the virtually reamed surface were assessed to determine the percentage of the intended component-bone interface consisting of cortical bone, here termed "cortical bone seating". This was then compared to positioning the component using a freehand technique. The freehand technique improved cortical bone seating in the osteoarthritic group with a mean (standard deviation) of 53.3% (14.3), while neutral alignment resulted in 36.7% (10.8), retroversion 40.4% (13.1), and inclination 39.3% (13.5), P < .001. A similar trend was observed in the normal group. The freehand method resulted in significantly improved cortical bone seating compared to the prescribed adjusted angles. These findings question the use of a one-size-fits-all-orientation and suggest that applying a technique that aims for maximum cortical fixation (freehand) may reduce the risk of aseptic loosening.

Recent research aims to leverage technology to further understand surgical recovery by using continuous data. Traditional metrics of readmission, flap failure, and patient-reported outcome measures are limited by poor accuracy and subjectivity. We aimed to validate smartphone-derived physical activity data to objectively measure and analyze trends in recovery following deep inferior epigastric perforator (DIEP) flap breast reconstruction. A single-center, retrospective study was conducted. Eligible participants who underwent DIEP reconstruction downloaded a bespoke smartphone application, which retrieved data from 1 month preoperatively to 12 months postoperatively. Physical activity was compared and validated against wearable activity monitor data from a previous study. Temporal trends were visualized using mean daily activity values over predefined intervals. Univariable linear regression assessed associations between clinical variables and short-term recovery. Forty-one patients were included in the study. Wearable activity monitor and smartphone datasets (n=10) showed a positive correlation (0.6379, p=0.0105) demonstrating concurrent validity. Analysis of recovery in DIEP patients (n=34) demonstrated a median return to baseline activity at 27 days (IQR 12 days). Physical activity decreased after DIEP, with mean daily activity dropping to 18% of baseline in the first 2 weeks (SD=11%, p<0.0001) before improving to 107% at 8-12 weeks (SD=78%, p=0.9999). Immediate postoperative reconstruction (p=0.046) and lack of postoperative complications (p=0.0063), were short-term predictors of physical activity. This study validates smartphone physical activity as an objective recovery metric in DIEP reconstruction. Future applications include developing recovery prediction models for shared decision-making, implementing perioperative interventions, and postoperative monitoring.