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Dr. Norma Depalma
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Academic Career Length
9Years (2018-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications9 November 2024 in Advanced Therapeutics
Journal Article
FCFederica Carnevali
Federica CarnevaliSFStefania Forciniti
Stefania ForcinitiVOValentina Onesto
Valentina OnestoASAnna Chiara Siciliano
Anna Chiara SicilianoHIHelena Iuele
Helena Iuele
Loretta L. del Mercato +9
The present review provides a comprehensive overview of the current state of in vitro cancer studies, focusing on recent advancements and ongoing in cell culture models and analyses techniques. Cancer cells grow in a complex and dynamic environment, interacting with various cellular components, such as stromal cells, cancer‐associated fibroblasts, immune cells, and the extracellular matrix (ECM). The ECM provides structural support and unique characteristics essential for tumorigenesis. Accurately modeling this intricate tumor microenvironment and precisely analyzing cell–cell and cell–ECM interactions are crucial for understanding cancer progression and therapeutic responses. Consequently, oncology research is advancing toward a) three‐dimensional tumor models, b) single‐cell level analyses, and c) live‐cell analyses. This review aims to elucidate current knowledge in this field, emphasizing the benefits these innovative approaches offer over traditional two‐dimensional models, bulk analyses, and endpoint measurements.
13 April 2019 in Aging Clinical and Experimental Research
Journal Article
NDNorma Depalma
Norma DepalmaDCD. Cassini
D. Cassini
MGM. Grieco
M. GriecoVBV. Barbieri
V. Barbieri
AAA. Altamura
A. Altamura
GBG. Baldazzi
G. Baldazzi
+2
Journal Article
NDNorma Depalma
Norma DepalmaSDStefano D’ugo
Stefano D’ugoFMFarshad Manoochehri
Farshad ManoochehriALAnnarita Libia
Annarita LibiaWSWilliam Sergi
William SergiMSMarcello Giuseppe Spampinato
Marcello Giuseppe Spampinato +7
Background: To date, no standardized protocols nor a quantitative assessment of the near-infrared fluorescence angiography with indocyanine green (NIR-ICG) are available. The aim of this study was to evaluate the timing of fluorescence as a reproducible parameter and its efficacy in predicting anastomotic leakage (AL) in colorectal surgery. Methods: A consecutive cohort of 108 patients undergoing minimally invasive elective procedures for colorectal cancer was prospectively enrolled. The difference between macro and microperfusion (ΔT) was obtained by calculating the timing of fluorescence at the level of iliac artery division and colonic wall, respectively. Results: Subjects with a ΔT ≥ 15.5± 0.5 s had a higher tendency to develop an AL (p < 0.01). The ΔT/heart rate interaction was found to predict AL with an odds ratio of 1.02 (p < 0.01); a cut-off threshold of 832 was identified (sensitivity 0.86, specificity 0.77). Perfusion parameters were also associated with a faster bowel motility resumption and a reduced length of hospital stay. Conclusions: The analysis of the timing of fluorescence provides a quantitative, easy evaluation of tissue perfusion. A ΔT/HR interaction ≥832 may be used as a real-time parameter to guide surgical decision making in colorectal surgery.
10 August 2018 in Updates in Surgery
Journal Article
MGMatteo Gregori
Matteo GregoriDCDiletta Cassini
Diletta CassiniNDNorma Depalma
Norma DepalmaMMMichelangelo Miccini
Michelangelo MicciniFMFarshad Manoochehri
Farshad ManoochehriGBGianandrea A. Baldazzi
Gianandrea A. Baldazzi1 June 2023 in Journal of Surgical Case Reports
Journal Article
WSWilliam Sergi
William SergiSDStefano D’uGo
Stefano D’uGo
ALAnnarita Libia
Annarita Libia
NDNorma Depalma
Norma DepalmaTMTiziana Marchese
Tiziana MarcheseMSMarcello Giuseppe Spampinato
Marcello Giuseppe Spampinato +5
Acinar cystic transformation (ACT), also known as ‘acinar cell cystadenoma’, is an uncommon cystic neoplasm of pancreas with unknown malignant potential. This case regards a woman with symptomatic pancreatic head ACT, revealed with pathological exam of specimen after pancreaticoduodenectomy. A 57-years-old patient presented mild hyperbilirubinemia and recurrent cholangitis; she underwent to ERCP, EUS and MRI, and these exams revealed a large cyst of the pancreatic head that caused biliary compression. The discussion of the case by the multidisciplinary group indicated surgical resection. Pancreatic ACT is so rare, and its preoperative diagnosis is difficult. The symptoms of the patients and the features of the cyst are the criteria to choose a surgical resection.
4 March 2024 in arXiv
Preprint
NDNorma Depalma
Norma DepalmaSUS. D Ugo
S. D Ugo
FMF. Manoochehri
F. ManoochehriALAnnarita Libia
Annarita LibiaWSW. Sergi
W. SergiMSM. G. Spampinato
M. G. Spampinato +7
Background: To date, no standardized protocols nor a quantitative assessment of the near-infrared fluorescence angiography with indocyanine green (NIR-ICG) are available. The aim of this study was to evaluate the timing of fluorescence as a reproducible parameter and its efficacy in predicting anastomotic leakage (AL) in colorectal surgery. Methods: A consecutive cohort of 108 patients undergoing minimally invasive elective procedures for colorectal cancer was prospectively enrolled. The difference between macro and microperfusion DeltaT was obtained by calculating the timing of fluorescence at the level of iliac artery division and colonic wall, respectively. Results: Subjects with a DeltaT higher 15.5 s had a higher tendency to develop an AL (p lower 0.01). The DeltaT/heart rate interaction was found to predict AL with an odds ratio of 1.02 (p lower 0.01); a cut-off threshold of 832 was identified (sensitivity 0.86, specificity 0.77). Perfusion parameters were also associated with a faster bowel motility resumption and a reduced length of hospital stay. Conclusions: The analysis of the timing of fluorescence provides a quantitative, easy evaluation of tissue perfusion. A DeltaT/HR interaction higher 832 may be used as a real-time parameter to guide surgical decision making in colorectal surgery.
About Me
Dr. Depalma was born in Grumo Appula (BA), Italy, and obtained her medical degree at the Faculty of Medicine of the University of Bari in 2013. In 2019, she completed her residency in General Surgery at the University of Rome “Sapienza”. Her training included several diplomas and masterclasses:
- In 2009, Clerkship IFMSA in Toluca, Mexico
- In 2010/11, ERASMUS project, Strasbourg, France
- In 2013, Clerkship IFMSA in Perth, Australia
- In 2016, Masterclass in Technical and Practical Course on Trauma Surgery
- In 2017, Masterclass in Abdominal Wall Surgery, EHS-ISHAWS
- In 2018, Diploma in Surgical Endoscopy, France
- In 2019, Diploma in Laparoscopic Techniques in Visceral Surgery, France
- In 2019, Diploma in Digestive Robotic Surgery, France
Dr. Depalma is a member of numerous international surgical associations, such as the EAES, the ACOI, and the SICCR. Dr. Depalma has eight years’ experience in general oncological surgery with special interest in colorectal surgery with a minimally invasive (laparoscopic, robotic, transanal) approach. Since 2018, she has been working at the Department of General and Oncologic Surgery at the “Vito Fazzi” Hospital, Lecce, Italy. Dr. Depalma took part as Principal Investigator in several international studies such as the ICRAL study, the COVID-19 AGICT study and the EAGLE Study. She has also been part of the COVIDSurg Collaborative Group. As first author, she wrote numerous original articles on new techniques in colorectal surgery.