The main objective was to determine the efficacy of Mindfulness-Based Interventions in improving the cognitive function of older adults (healthy adults or adults with mild cognitive impairment).A s...

Type 2 diabetes mellitus (T2D) is a metabolic disease reaching pandemic levels worldwide. In parallel, Alzheimer’s disease (AD) and vascular dementia (VaD) are the two leading causes of dementia in an increasingly long-living Western society. Numerous epidemiological studies support the role of T2D as a risk factor for the development of dementia. However, few basic science studies have focused on the possible mechanisms involved in this relationship. On the other hand, this review of the literature also aims to explore the relationship between T2D, AD and VaD. The data found show that there are several alterations in the central nervous system that may be promoting the development of T2D. In addition, there are some mechanisms by which T2D may contribute to the development of neurodegenerative diseases such as AD or VaD.

Background/Objectives: The link between stress and performance in instrumental activities of daily living (IADLs) and participation in older adults is gaining importance. The existing evidence is based on single measures of salivary cortisol levels; therefore, there is a need for more comprehensive studies that incorporate long-term measurements of cortisol concentrations as indicators of chronic stress. In consequence, the objective is to determine whether perceived stress, hair cortisol concentration, and psychological resilience are related to IADLs and participation in older individuals. Methods: A sample of 63 individuals with a mean age of 76.5 years underwent an assessment of stress variables (Perceived Stress Scale, hair cortisol concentration, and Resilience Scale), IADLs (UPSA Scale), and participation (PART-O Scale). Using the stress variables as factors, multiple linear regressions were conducted to predict UPSA and PART-O scores and their respective subscales. The correlation between UPSA and PART-O was also examined. Results: After controlling for age, gender, and cognitive status, resilience emerged as the sole independent predictor of overall scores on both scales, as well as on two subscales: UPSA-Communication and PART-O-Others, for which hair cortisol was also a predictor. The effect size of the association between UPSA and PART-O scores was small. Conclusions: psychological resilience is not only a protective variable against stress but also appears to be associated with instrumental functioning and social participation in older adults. This finding suggests that resilience plays a role in facilitating IADLs and participation among the elderly population.

Background/Objectives: To examine the association between body composition and glucose tolerance in young adults with normal weight, overweight, or obesity. Methods: This observational case–control study included 154 healthy individuals aged 18–25 years. Participants were categorized into three BMI-based groups and underwent anthropometric and body composition assessments using bioelectrical impedance. Glucose tolerance was evaluated via oral glucose tolerance testing, with capillary blood samples collected at baseline and at 30, 60, 90, and 120 min post load. Results: Compared to the normal-weight group, overweight and obese individuals exhibited significantly higher body weight, BMI, visceral and total fat percentages, and reduced muscle mass. Obese participants also showed a significantly greater glucose area under the curve (AUC) and higher fasting and post-load glucose levels. Visceral fat was positively correlated with metabolic impairment. These results indicate a progressive decline in glucose tolerance associated with increasing adiposity and reduced lean mass. Conclusions: Young adults with elevated BMI already demonstrate marked alterations in body composition and impaired glucose tolerance, even in the absence of overt metabolic disease. These findings underscore the importance of the early identification of at-risk individuals using simple, non-invasive tools. Preventive strategies promoting healthy body composition in early adulthood may reduce the future risk of diabetes and its associated complications.

BackgroundThe risk of cognitive decline in older adults makes it necessary to design training programs for the improvement of cognition.AimsTo determine the efficacy of applying a combined program of computerized cognitive training (CCT) and mindfulness for improving cognition and mood and quality of life in people aged 60 years and older, compared with using both interventions separately.MethodsAdults, older than 95 years were assigned to groups that subsequently received one of the three interventions (CCT, mindfulness, and combined). Cognitive, emotional, and quality of life assessment instruments were administered pre- and post-intervention. The standardized individual change was determined, and one-factor ANOVAs and ANCOVAs were conducted to test between-group differences.ResultsAfter controlling for confounding factors, greater significant improvements were obtained in the combined group compared with the CCT and mindfulness groups in selective attention (median effect size) and abstract reasoning (large effect size). No significant differences were found in the rest of cognitive variables, mood or quality of life.ConclusionThe findings indicate that, with the same investment of time, combining CCT and mindfulness effectively improves selective attention and abstract reasoning, in older adults. This combination of strategies might have implications for the improvement of cognitive impairment in older adults.

Participation has been shown to be a protective factor for cognition in older adults, but instruments to assess it are limited. The main objective was to determine the validity of two scoring systems (direct vs transformed) for the Participation Assessment with Recombined Tools-Objective (PART-O) by applying structural equation modeling to the relationship between the subscales and the cognitive functions, in a sample of 245 people over 60 years of age. The transformed scores model showed stronger relationships and larger explained variance in overall participation (55.4% vs 37.4%), especially in the Social Relations subscale (31.4% vs 14.6% ). Participation was a direct predictor of cognitive functions in both models. Age and depression inversely influenced participation in the transformed scores model. The proposed score transformation for the PART-O provides a more appropriate measurement of the older adults’ participation. Participation has a mediating role in the relationship between cognition and both age and depression.