Silvio Danese has been a gastroenterologist and professor of gastroenterology at Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Milan, Italy, since October 2021, where he is head of the Gastroenterology and Gastrointestinal Endoscopy Unit. Before that, he was head of the IBD Centre and ImmunoCentre at IRCCS Humanitas, Rozzano, Milan, Italy, and professor of gastroenterology at Humanitas University. He trained in gastroenterology at Policlinico Gemelli, Rome, and graduated with a Ph.D., working from 2001 to 2004 in Dr. Claudio Fiocchi’s laboratory at Case Western Reserve University, Cleveland, Ohio, USA. His main research area of interest is the investigation of the fundamental mechanisms underlying IBD pathogenesis, while his daily clinical activity is related to IBD service. He is actively involved in many international clinical trials for IBD and has published many papers in several journals, including the New England Journal of Medicine, Lancet, Gastroenterology, Gut, and the Journal of Clinical Investigation. He is a member of many organizations related to the IBD field, including the European Crohn´s and Colitis Organization (ECCO), where he is a past president (2018–2020).