Breast cancer is a cancer with global prevalence and a surge in the number of cases with each passing year. With the advancement in science and technology, significant progress has been achieved in the prevention and treatment of breast cancer to make ends meet. The scientific intradisciplinary subject of “metabolomics” examines every metabolite found in a cell, tissue, system, or organism from different sources of samples. In the case of breast cancer, little is known about the regulatory pathways that could be resolved through metabolic reprogramming. Evidence related to the significant changes taking place during the onset and prognosis of breast cancer can be obtained using metabolomics. Innovative metabolomics approaches identify metabolites that lead to the discovery of biomarkers for breast cancer therapy, diagnosis, and early detection. The use of diverse analytical methods and instruments for metabolomics includes Magnetic Resonance Spectroscopy, LC/MS, UPLC/MS, etc., which, along with their high-throughput analysis, give insights into the metabolites and the molecular pathways involved. For instance, metabolome research has led to the discovery of the glutamate-to-glutamate ratio and aerobic glycolysis as biomarkers in breast cancer. The present review comprehends the updates in metabolomic research and its processes that contribute to breast cancer prognosis and metastasis. The metabolome holds a future, and this review is an attempt to amalgamate the present relevant literature that might yield crucial insights for creating innovative therapeutic strategies aimed at addressing metastatic breast cancer.

The world has been facing a back-to-back hit to life after widespread of viruses since the time of COVID-19. The pandemic had a devastating effect and created history in mankind, but that was not enough for the time. The viruses are been known to be the deadliest microbes by virtue of their ability to reside as inactive for long time and become active again along with new variants when the conditions are favourable. One such noted spread out of virus has been that of Monkeypox Virus in humans. A zoonotic orthopoxvirus that can infect humans, the monkeypox virus (MPV) can cause disease with varied morbidity and death in humans. It has been demonstrated that members of the Orthopoxvirus genus decrease antiviral cell defences, take advantage of host cell machinery, and postpone infection-induced cell death. The name Monkeypox was after its first observation in Macaque monkey but the virus’s origin has been linked to a number of rodents and small mammals. The virus was endemic to Africa and is closely related to notorious variola (smallpox) virus. They both affect people with a febrile rash sickness that is similar to smallpox but has less severity. Monkeypox can spread from person to person and it is frequently related to breathing droplets or direct contact with mucocutaneous lesions of an affected person. There is now no cure available for those who are affected, yet supporting therapies can be used to help people with their symptoms. To better comprehend and prevent human infections, additional study is required on the epidemiology, ecology, mutations and biology of the new virus strains in endemic locations.

The nanoparticle is one of the most intensively studied areas in science ranging from engineering to medical fields and has been a center of attraction that is explored to find new and promising dimensions for its use. These nanoparticles have obtained eminence because of their potential efficacy, shape, and size. In the field of nanoscience, the use of natural resources is an emerging topic of interest that has been taken into consideration due to the presence of a reservoir of a priceless wellspring of novel and new chemical entities that have a therapeutic effect. The system has found its space in the treatment of many diseases, including Diabetes, Neurological disorders, Cardiovascular Disorders, and even cancer. At present, cancer is one of the most common causes of death all over the world. Various drugs are used to treat numerous types of cancers, but at the same time, they are found to be harmful to the patient and produce several side effects. To meet the gap, herbal nanoparticles have been studied and are found to be non-hazardous and environmentally friendly. Herbal nanoparticles are synthesized to target various biological pathways that induce cancer and pieces of evidence have shown comparable efficacy like other drugs that have been used conventionally for cancer treatment. The review highlights the mechanism of action and prospects of the nanotechnological approach using phytochemicals for the treatment of cancer and will help to bridge the gap between herbal nanotechnology and current knowledge related to it.