Bret D Ulery

Dr. Bret D Ulery

orcid

Research Focus & Metrics

Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 August 2015 in Current Opinion in Biotechnology
Verified
Journal Article
Closed access
JSJosiah D Smith
Josiah D Smith
LMLogan D Morton
Logan D Morton
BUBret D Ulery
Bret D Ulery

7 May 2018 in ACS Biomaterials Science & Engineering
Verified
Journal Article
Closed access
RZRui Zhang
Rui Zhang
JSJosiah D. Smith
Josiah D. Smith
BABrittany N. Allen
Brittany N. Allen
JKJake S. Kramer
Jake S. Kramer
MSMartin Schauflinger
Martin Schauflinger
BUBret D Ulery
Bret D Ulery

24 April 2018 in ACS Biomaterials Science & Engineering
Verified
Journal Article
Closed access
RZRui Zhang
Rui Zhang
LMLogan D. Morton
Logan D. Morton
JSJosiah D. Smith
Josiah D. Smith
FGFabio Gallazzi
Fabio Gallazzi
TWTommi Anna White
Tommi Anna White
BUBret D Ulery
Bret D Ulery

1 June 2018 in The AAPS Journal
Verified
Journal Article
Closed access
PDF file
RZRui Zhang
Rui Zhang
JKJake S. Kramer
Jake S. Kramer
JSJosiah D. Smith
Josiah D. Smith
BABrittany N. Allen
Brittany N. Allen
CLCaitlin N. Leeper
Caitlin N. Leeper
BUBret D Ulery
Bret D Ulery

22 October 2018 in Physical Biology
Verified
Journal Article
Closed access
PDF file
JSJosiah D Smith
Josiah D Smith
LCLeah N Cardwell
Leah N Cardwell
David PorcianiDavid Porciani
David Porciani
JNJulie A Nguyen
Julie A Nguyen
RZRui Zhang
Rui Zhang
BUBret D Ulery
Bret D Ulery
Peptide amphiphile micelles (PAMs) are attractive vehicles for the delivery of a variety of therapeutic and prophylactic peptides. However, a key limitation of PAMs is their lack of preferential targeting ability. In this paper, we describe our design of a PAM system that incorporates a DNA oligonucleotide amphiphile (antitail amphiphile—AA) to form A/PAMs. A cell-targeting DNA aptamer with a 3′ extension sequence (tail) complementary to the AA is annealed to the surface to form aptamer-displaying PAMs (Aptamer~A/PAMs). Aptamer~A/PAMs are small, anionic, stable nanoparticles capable of delivering a large mass percentage peptide amphiphile (PA) compared to targeting DNA components. Aptamer~A/PAMs are stable for over 4 h in the presence of biological fluids. Additionally, the aptamer retains its cell-targeting properties when annealed to the A/PAM, thus leading to enhanced delivery to a specifically-targeted B-cell leukemia cell line. This exciting modular technology can be readily used with a library of different targeting aptamers and PAs, capable of improving the bioavailability and potency of the peptide cargo.

1 June 2019 in International Journal of Biological Macromolecules
Verified
Journal Article
Closed access
SGSoheila Ali Akbari Ghavimi
Soheila Ali Akbari Ghavimi
ELEthan S. Lungren
Ethan S. Lungren
TFTrent J. Faulkner
Trent J. Faulkner
MJMary A. Josselet
Mary A. Josselet
YWYing Wu
Ying Wu
BUBret D Ulery
Bret D Ulery