Fifth generation (5G) wireless networks promise to revolutionize the way we communicate and connect to the internet. However, as with any new technology, 5G networks also bring new security challenges that need to be addressed. One of the key areas of concern is physical layer security, which refers to the protection of the physical layer of the network against attacks that could compromise its integrity and availability. In this systematic review, we examined the current state of research on physical layer security in 5G wireless networks. Our search identified 36 relevant studies that focused on various aspects of physical layer security, including threat models, vulnerabilities, and mitigation techniques. The findings of the review suggest that whereas some progress has been made in developing physical layer security solutions for 5G networks, such as advancements in multi-antenna systems, interference exploitation, secrecy metrics, and understanding the impact of fading channels, there is still much work to be performed. Further research is needed to develop more effective security solutions and risk assessment frameworks, as well as to evaluate the effectiveness of existing solutions under different conditions and scenarios. Collaboration between industry, academia, and government agencies will also be essential to address the physical layer security challenges in 5G wireless networks. The idea of the proposal is physical layer security in 5G wireless networks. We conduct proper research on this paper and analyze 45 papers to understand this topic in depth. Our research’s integrity is built on a commitment to our core principles, which include objectivity, honesty, transparency, fairness, accountability, and stewardship. These managing ideologies aid in confirming that knowledge is innovative through the research zone.