Kostis Giannakopoulos

Dr. Kostis Giannakopoulos

School of Dentistry, European University Cyprus, Nicosia, Lefkosía, Cyprus
orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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28 December 2023 in Journal of Medical Internet Research
Verified
Journal Article
Open access
KGKostis Giannakopoulos
Kostis Giannakopoulos
AKArgyro Kavadella Kavadella
Argyro Kavadella Kavadella
ASAnas Aaqel Salim
Anas Aaqel Salim
VSVassilis Stamatopoulos
Vassilis Stamatopoulos
EKEleftherios G. Kaklamanos
Eleftherios G. Kaklamanos
Background: The increasing application of generative artificial intelligence large language models (LLMs) in various fields, including dentistry, raises questions about their accuracy. Objective: This study aims to comparatively evaluate the answers provided by 4 LLMs, namely Bard (Google LLC), ChatGPT-3.5 and ChatGPT-4 (OpenAI), and Bing Chat (Microsoft Corp), to clinically relevant questions from the field of dentistry. Methods: The LLMs were queried with 20 open-type, clinical dentistry–related questions from different disciplines, developed by the respective faculty of the School of Dentistry, European University Cyprus. The LLMs’ answers were graded 0 (minimum) to 10 (maximum) points against strong, traditionally collected scientific evidence, such as guidelines and consensus statements, using a rubric, as if they were examination questions posed to students, by 2 experienced faculty members. The scores were statistically compared to identify the best-performing model using the Friedman and Wilcoxon tests. Moreover, the evaluators were asked to provide a qualitative evaluation of the comprehensiveness, scientific accuracy, clarity, and relevance of the LLMs’ answers. Results: Overall, no statistically significant difference was detected between the scores given by the 2 evaluators; therefore, an average score was computed for every LLM. Although ChatGPT-4 statistically outperformed ChatGPT-3.5 (P=.008), Bing Chat (P=.049), and Bard (P=.045), all models occasionally exhibited inaccuracies, generality, outdated content, and a lack of source references. The evaluators noted instances where the LLMs delivered irrelevant information, vague answers, or information that was not fully accurate. Conclusions: This study demonstrates that although LLMs hold promising potential as an aid in the implementation of evidence-based dentistry, their current limitations can lead to potentially harmful health care decisions if not used judiciously. Therefore, these tools should not replace the dentist’s critical thinking and in-depth understanding of the subject matter. Further research, clinical validation, and model improvements are necessary for these tools to be fully integrated into dental practice. Dental practitioners must be aware of the limitations of LLMs, as their imprudent use could potentially impact patient care. Regulatory measures should be established to oversee the use of these evolving technologies.

31 January 2024 in JMIR Medical Education
Verified
Journal Article
Open access
AKArgyro Kavadella Kavadella
Argyro Kavadella Kavadella
MSMarco Antonio Dias da Silva
Marco Antonio Dias da Silva
EKEleftherios G. Kaklamanos
Eleftherios G. Kaklamanos
VSVasileios Stamatopoulos
Vasileios Stamatopoulos
KGKostis Giannakopoulos
Kostis Giannakopoulos
Background: The recent artificial intelligence tool ChatGPT seems to offer a range of benefits in academic education while also raising concerns. Relevant literature encompasses issues of plagiarism and academic dishonesty, as well as pedagogy and educational affordances; yet, no real-life implementation of ChatGPT in the educational process has been reported to our knowledge so far. Objective: This mixed methods study aimed to evaluate the implementation of ChatGPT in the educational process, both quantitatively and qualitatively. Methods: In March 2023, a total of 77 second-year dental students of the European University Cyprus were divided into 2 groups and asked to compose a learning assignment on “Radiation Biology and Radiation Protection in the Dental Office,” working collaboratively in small subgroups, as part of the educational semester program of the Dentomaxillofacial Radiology module. Careful planning ensured a seamless integration of ChatGPT, addressing potential challenges. One group searched the internet for scientific resources to perform the task and the other group used ChatGPT for this purpose. Both groups developed a PowerPoint (Microsoft Corp) presentation based on their research and presented it in class. The ChatGPT group students additionally registered all interactions with the language model during the prompting process and evaluated the final outcome; they also answered an open-ended evaluation questionnaire, including questions on their learning experience. Finally, all students undertook a knowledge examination on the topic, and the grades between the 2 groups were compared statistically, whereas the free-text comments of the questionnaires were thematically analyzed. Results: Out of the 77 students, 39 were assigned to the ChatGPT group and 38 to the literature research group. Seventy students undertook the multiple choice question knowledge examination, and examination grades ranged from 5 to 10 on the 0-10 grading scale. The Mann-Whitney U test showed that students of the ChatGPT group performed significantly better (P=.045) than students of the literature research group. The evaluation questionnaires revealed the benefits (human-like interface, immediate response, and wide knowledge base), the limitations (need for rephrasing the prompts to get a relevant answer, general content, false citations, and incapability to provide images or videos), and the prospects (in education, clinical practice, continuing education, and research) of ChatGPT. Conclusions: Students using ChatGPT for their learning assignments performed significantly better in the knowledge examination than their fellow students who used the literature research methodology. Students adapted quickly to the technological environment of the language model, recognized its opportunities and limitations, and used it creatively and efficiently. Implications for practice: the study underscores the adaptability of students to technological innovations including ChatGPT and its potential to enhance educational outcomes. Educators should consider integrating ChatGPT into curriculum design; awareness programs are warranted to educate both students and educators about the limitations of ChatGPT, encouraging critical engagement and responsible use.

22 February 2025 in European Archives of Paediatric Dentistry
Verified
Journal Article
Open access
PDF file
ADAnastasia Dermata
Anastasia Dermata
AAArhakis Aristidis
Arhakis Aristidis
MMMiltiadis A. Makrygiannakis
Miltiadis A. Makrygiannakis
KGKostis Giannakopoulos
Kostis Giannakopoulos
EKEleftherios G. Kaklamanos
Eleftherios G. Kaklamanos
Purpose: The use of large language models (LLMs) in generative artificial intelligence (AI) is rapidly increasing in dentistry. However, their reliability is yet to be fully founded. This study aims to evaluate the diagnostic accuracy, clinical applicability, and patient education potential of LLMs in paediatric dentistry, by evaluating the responses of six LLMs: Google AI’s Gemini and Gemini Advanced, OpenAI’s ChatGPT-3.5, -4o and -4, and Microsoft’s Copilot. Methods: Ten open-type clinical questions, relevant to paediatric dentistry were posed to the LLMs. The responses were graded by two independent evaluators from 0 to 10 using a detailed rubric. After 4 weeks, answers were reevaluated to assess intra-evaluator reliability. Statistical comparisons used Friedman’s and Wilcoxon’s and Kruskal–Wallis tests to assess the model that provided the most comprehensive, accurate, explicit and relevant answers. Results: Variations of results were noted. Chat GPT 4 answers were scored as the best (average score 8.08), followed by the answers of Gemini Advanced (8.06), ChatGPT 4o (8.01), ChatGPT 3.5 (7.61), Gemini (7,32) and Copilot (5.41). Statistical analysis revealed that Chat GPT 4 outperformed all other LLMs, and the difference was statistically significant. Despite variations and different responses to the same queries, remarkable similarities were observed. Except for Copilot, all chatbots managed to achieve a score level above 6.5 on all queries. Conclusion: This study demonstrates the potential use of language models (LLMs) in supporting evidence-based paediatric dentistry. Nevertheless, they cannot be regarded as completely trustworthy. Dental professionals should critically use AI models as supportive tools and not as a substitute of overall scientific knowledge and critical thinking.

12 June 2025 in European Journal of Orthodontics
Verified
Journal Article
Open access
MMMiltiadis A. Makrygiannakis
Miltiadis A. Makrygiannakis
KGKostis Giannakopoulos
Kostis Giannakopoulos
AKArgyro Kavadella
Argyro Kavadella
Dimitrios ParaskevisDimitrios Paraskevis
Dimitrios Paraskevis
EKEleftherios G. Kaklamanos
Eleftherios G. Kaklamanos
Background/Objectives: Recent advances in AI have enabled its application in dentistry. This study assessed the diagnostic accuracy of an AI-based model (Diagnocat™) in detecting congenitally missing and supernumerary teeth on panoramic radiographs. Materials/Methods: Three groups of 50 orthopantomograms each—control, congenitally missing, and supernumerary teeth—were evaluated by two human observers and Diagnocat™. Diagnostic performance was compared using the Wilcoxon Signed Rank and McNemar’s tests. Agreement was measured using Cohen’s Kappa, and diagnostic metrics (sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV)) were computed using IBM SPSS 29.0. Results: For congenitally missing teeth, Cohen’s Kappa indicated strong agreement (0.91); however, significant differences were found in the diagnostic performance (p < 0.01). The model exhibited 84.7% sensitivity, 100.0% specificity, 100.0% PPV, and 99.4% NPV. For supernumerary teeth, the agreement was moderate (Kappa = 0.60), with significant differences in the diagnostic performance (p < 0.001). Sensitivity was 43.9%, while specificity, PPV, and NPV were 100.0%, 100.0%, and 98.9%, respectively. Limitations: Using convenience sampling and a retrospective design may affect generalizability and applicability. Conclusions/Implications: Although the AI-based model shows promise, it is not yet able to replace human assessment as the standard for detecting missing and supernumerary teeth in panoramic radiographs.

26 December 2023 in Dentistry Journal
Verified
Journal Article
Open access
PDF file
KGKostis Giannakopoulos
Kostis Giannakopoulos
PLPersefoni Lambrou-Christodoulou
Persefoni Lambrou-Christodoulou
EKEleftherios G. Kaklamanos
Eleftherios G. Kaklamanos
This study aimed to evaluate the awareness, comprehension, and practices concerning forensic odontology among dental students and faculty at a Dental School in Cyprus. An online, cross-sectional, descriptive survey, employing an adapted, self-administered questionnaire, was disseminated to all dental students and faculty at the School of Dentistry, European University Cyprus, in November 2022. The survey assessed participants’ demographic information and explored their awareness with questions alluding to knowledge, attitudes and practices in forensic dentistry. Of those surveyed, 47 faculty members and 304 students responded, yielding response rates of 66.2% and 80%, respectively. Statistical analysis, including Kendall’s tau test and χ2 test were employed to examine correlations and associations, with Cramer’s V used to measure the strength of significant associations. The predetermined significance level was α = 0.05. Awareness levels were assessed through participants’ responses to specific questions in the survey. It was revealed that 87% of faculty and 65% of students were familiar with forensic odontology. A noteworthy 94% of faculty and 85% of students recognized teeth as DNA repositories. A high percentage, 98% of faculty and 89% of students, acknowledged the role of forensic odontology in the identification of criminals and deceased individuals. Awareness of age estimation through dental eruption patterns was evident in 85% of faculty and 81.6% of students. A substantial proportion (80% of faculty) maintained dental records, while 78% of students recognized the importance of dental record-keeping in ensuring quality care. Interestingly, 57% of students and 64% of faculty were aware of the possibility of dentists testifying as expert witnesses. The majority, 95.7% of faculty and 85% of students, concurred that physical harm, scars, and behavioral alterations predominantly indicate child abuse. The findings, revealing robust awareness among respondents, underscore the importance of enhancing faculty engagement in relevant seminars to further strengthen their knowledge. Additionally, emphasizing improved record-keeping practices for potential forensic applications emerges as a crucial aspect. These insights have implications for refining dental education in Cyprus and enhancing forensic practices by promoting ongoing professional development and emphasizing meticulous record-keeping within the dental community.

30 March 2023 in European Journal of Dental Education
Verified
Journal Article
Open access
KGKostis Giannakopoulos
Kostis Giannakopoulos
AKArgyro Kavadella
Argyro Kavadella
KKKaterina Kavvadia
Katerina Kavvadia
AYAndreas Yiallouris
Andreas Yiallouris
EKEleftherios G. Kaklamanos
Eleftherios G. Kaklamanos
Introduction: During the recent pandemic, e-learning and e-assessment methods have been implemented worldwide, providing opportunities for further implementation in the dental curriculum. This study aims to research the dental students' and dental faculty's perceptions of online exams with e-invigilation. Materials and Methods: Online questionnaires were developed and delivered, after three semesters of online exams, to all students and faculty. Descriptive statistics were performed, and answers were grouped into Principal Components (PC) using Principal Component Analysis (PCA). Statistical significance was set at p <.05. Results: Two-hundred and sixty dental students (83.7%) and 24 dental faculty members (63.1%) answered the online questionnaires. PCA of students' responses revealed 4 PC, 'University support to students', 'Comparison between online and face-to-face exams', 'Preparation for the online exams' and 'Attitudes towards the technology used for the online exams'. PCA of faculty responses revealed 5 PC: 'Comparison between online and face-to-face exams', 'University support to faculty', 'Faculty attitudes towards the exam procedures', 'Human factors associated with the exam procedures' and 'Exam invigilation'. The overall satisfaction was high for both staff and students (higher for students and female staff). Students with previous experience in online exams scored more positively than first-year students. University support, process-related stress and e-invigilation were highlighted. Conclusions: The overall satisfaction with the e-exams was high, despite the technical problems, time-consuming processes and related stress. University support (training, IT support and resources) and mock exams emerged as important elements of online exams, as was the e-invigilation, which students perceived as efficient and non-intrusive.