The shipping industry is vital to global trade. Unfortunately, this industry is negatively impacted on a large scale by biofouling, a process whereby unwanted organisms accumulate on submerged surfaces, massively affecting traveling speed and fuel consumption. Fortunately, antifouling coatings have been developed to combat this problem. This review summarizes the process of biofouling and briefly discusses the history of antifouling coating development. Moreover, eight major antifouling coatings are reviewed, including bionic microstructure, self-polishing, fouling and desorption, zwitterionic polymer, self-assembled thin-layer, liquid-smooth surface, conductive, and photocatalytic antifouling coatings. The technical principles, innovation, and advancement of each coating are expounded, and the relevant research progress is discussed. Finally, the remaining issues and challenges in antifouling coatings are discussed, along with their prospects.