Sushma Anand

Dr. Sushma Anand

orcid
Senior Research Fellow, Centre for Eye Research Australia

Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 February 2016 in Journal of Molecular Biology
Verified
Journal Article
Closed access
SKShivakumar Keerthikumar
Shivakumar Keerthikumar
DCDavid Chisanga
David Chisanga
DADinuka Ariyaratne
Dinuka Ariyaratne
HSHaidar Al Saffar
Haidar Al Saffar
SASushma Anand
Sushma Anand
Suresh MathivananSuresh Mathivanan
Suresh Mathivanan

28 February 2017 in Nature Methods
Verified
Journal Article
Closed access
ECEV-TRACK Consortium
EV-TRACK Consortium
JDJan Van Deun
Jan Van Deun
PMPieter Mestdagh
Pieter Mestdagh
PAPatrizia Agostinis
Patrizia Agostinis
ÖAÖzden Akay
Özden Akay
AHAn Hendrix
An Hendrix

1 December 2019 in Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Verified
Journal Article
Closed access
SASushma Anand
Sushma Anand
MSMonisha Samuel
Monisha Samuel
SKSharad Kumar
Sharad Kumar
Suresh MathivananSuresh Mathivanan
Suresh Mathivanan

19 July 2017 in Scientific Reports
Verified
Journal Article
Open access
PDF file
MSMonisha Samuel
Monisha Samuel
DCDavid Chisanga
David Chisanga
MLMichael Liem
Michael Liem
SKShivakumar Keerthikumar
Shivakumar Keerthikumar
SASushma Anand
Sushma Anand
Suresh MathivananSuresh Mathivanan
Suresh Mathivanan
Exosomes are extracellular vesicles secreted by multiple cell types into the extracellular space. They contain cell-state specific cargos which often reflects the (patho)physiological condition of the cells/organism. Milk contains high amounts of exosomes and it is unclear whether their cargo is altered based on the lactation stage of the organism. Here, we isolated exosomes from bovine milk that were obtained at various stages of lactation and examined the content by quantitative proteomics. Exosomes were isolated by OptiPrep density gradient centrifugation from milk obtained from cow after 24, 48 and 72 h post calving. As control, exosomes were also isolated from cows during mid-lactation period which has been referred to as mature milk (MM). Biochemical and biophysical characterization of exosomes revealed the high abundance of exosomes in colostrum and MM samples. Quantitative proteomics analysis highlighted the change in the proteomic cargo of exosomes based on the lactation state of the cow. Functional enrichment analysis revealed that exosomes from colostrum are significantly enriched with proteins that can potentially regulate the immune response and growth. This study highlights the importance of exosomes in colostrum and hence opens up new avenues to exploit these vesicles in the regulation of the immune response and growth.

15 December 2016
Verified
Book Chapter
Closed access
PDF file
SASushma Anand
Sushma Anand
MSMonisha Samuel
Monisha Samuel
CAChing-Seng Ang
Ching-Seng Ang
SKShivakumar Keerthikumar
Shivakumar Keerthikumar
Suresh MathivananSuresh Mathivanan
Suresh Mathivanan

20 August 2018 in Proteomics
Verified
Journal Article
Closed access
PDF file
SASushma Anand
Sushma Anand
NFNatalie Foot
Natalie Foot
CAChing‐Seng Ang
Ching‐Seng Ang
KGKelly M. Gembus
Kelly M. Gembus
SKShivakumar Keerthikumar
Shivakumar Keerthikumar
SKSharad Kumar
Sharad Kumar