Objective: MicroRNAs (miRNAs) have emerged as promising biomarkers for diagnosis and prognosis in laryngeal squamous cell carcinoma (LSCC). This study investigates the expression patterns of specific cancer-associated miRNAs in early and advanced stage LSCC to evaluate their potential role in disease progression. Methods: The expression levels of miRNA-21, miRNA-802, miRNA-29 and miRNA-9 were analysed in formalin-fixed paraffin-embedded (FFPE) tissues from 44 LSCC patients (20 early stage, 24 advanced stage) using quantitative multiplex RT-PCR. Tissue samples were analysed retrospectively. Results: The expression level of hsa-miR-9a expression was significantly upregulated (5.2-fold) in advanced stage patients compared to the early stage group (p = 0.0088). Similarly, hsa-miR-802a showed significantly higher expression (9.2-fold) in advanced stage patients compared to early stage patients (p = 0.005). No significant differences in miRNA-21 and miRNA-29 expression levels were observed between the groups. Conclusion: As a result of the study, elevated miRNA levels in advanced stage patients can be used in targeted therapy and evaluated as a treatment option in LSCC patients.

Amaç: Biz çalışmamızda; kulak çınlaması olan hastaların bedensel belirtileri büyütme düzeylerini, depresif semptomlarını, aleksitiminin varlığı ve şiddetini sağlıklı kontrollerle karşılaştırarak incelemeyi amaçladık. Gereç ve Yöntemler: Çalışmamıza Kulak Burun Boğaz ve Baş Boyun Cerrahisi polikliniğinde tinnitus tanısı konulan hastalar ve demografik veriler ile eşleşebilecek sağlıklı kontroller alındı. Toplamda 141 kişi; tinnitus tanılı 80 hasta ve sağlıklı kontrol grubu 61 kişi alındı. Tüm katılımcılara; Beck Depresyon Ölçeği (BDÖ), Toronto Aleksitimi Ölçeği (TAÖ-20), Bedensel Duyumları Abartma Ölçeği (BDAÖ) ve Tinnitus Engellilik Anketi (TEA) uygulandı. Bulgular: Hasta grubu ve sağlıklı kontrol grubunun BDAÖ puanları istatistiksel olarak farklı değildi. TAÖ için ise; hasta grubunda alt ölçeklerde puanlar yüksek hesap edilse de istatistiksel olarak anlamlı farklılık sadece toplam puanda saptandı (p=0.015). Depresyon ölçeği skorları ise; hasta grubunda daha yüksek görünse de istatistiksel olarak anlamlı farklılık tespit edilmedi (Hasta grubunda=13,00; kontrol grubunda=11,00; p=0,084). TEA ile BDÖ, BDAÖ, TAÖ-20 toplam skorları ve duyguları tanımada güçlük alt boyut skorları pozitif ilişkili olarak saptandı (r değerleri sırası=0,537;0,271;0,222;0,427 ve p değerleri sırası ile p<0,01; p<0,05; p<0,05; p<0,01). Sonuç: Elde ettiğimiz sonuçlardan yola çıkarak; çınlama hastalarının rutin uygulanan tanı ve tedavi prosedürlerinin yanında ruhsal olarak dikkatlice değerlendirilmeleri, var olan psikiyatrik semptomların iyileştirilmesi, psiko-sosyal olarak hastaların desteklenmeleri önerilmektedir Aim: In our study, we aimed to examine the amplification levels of somatic symptoms in patients with tinnitus, the presence and severity of depressive symptoms, and alexithymia by comparing them with healthy controls. Material and Methods: Patients diagnosed with tinnitus in the Ear Nose Throat and Head Neck Surgery outpatient clinic and healthy controls that could match the demographic data were included in our study. 141 people in total; 80 patients with tinnitus and 61 healthy control groups were included. To all participants, the Beck Depression Inventory (BDI), Toronto Alexithymia Scale (TAS-20), the Somatosensory Amplification Scale (SAS), and Tinnitus Handicap Inventory (THI) were applied. Results: The SAS scores of the patient and healthy control groups were not statistically different. For TAS-20, although the scores in the subscales were calculated high in the patient group, a statistically significant difference was found only in the total score (p=0.015). Although the depression scale score was higher in the patient group, no statistically significant difference was detected (Patients group=13.00; control group=11.00; p=0.084). THI, BDI, SAS, and TAS-20 total scores and difficulty in recognizing emotions sub-dimension scores were positively correlated (r values respectively=0.537; 0.271; 0.222; 0.427, and p values respectively; p<0.01; p<0.05; p<0.05; p<0.01). Conclusion: Based on the results we obtained, in addition to routine diagnosis and treatment procedures, it is recommended that patients with tinnitus be carefully evaluated psychologically, the existing psychiatric symptoms.

Aims A number of studies link ear and paranasal sinus disorders even though correlation between the development of the paranasal sinuses and the mastoid has not been demonstrated clearly. In this study, we examined temporal bone computed tomography (CT) scans to calculate mastoid and paranasal sinus volumes using three-dimensional (3D) reconstruction in patients with unilateral nonsuppurative chronic otitis media (COM) and investigated whether there was a correlation between mastoid and paranasal sinus volumes. Methods Of 85 patients with unilateral nonsuppurative COM, 51 patients who underwent unilateral type 1 tympanoplasty and has temporal bone CTs were included in the study. Open-access Horos DICOM Viewer software (Horos Project, Geneva, Switzerland) was used to measure the volumes of sphenoid, maxillary and frontal sinuses and mastoid air cells. Maxillary, frontal, sphenoid sinus and mastoid air cell volumes were calculated and analyzed. Results Unilateral nonsuppurative chronic otitis media caused a statistically significant decrease in ipsilateral mastoid pneumatization, causing an asymmetry between two mastoid air cell systems. Ipsilateral frontal and maxillary sinus volumes were decreased and ipsilateral sphenoid sinus volume increased, however these findings were not statistically significant. Conclusion Middle ear pathologies cause mastoid cell hypopneumatization. Care should be taken as these changes may also have an effect on the paranasal sinuses. Existing pathologies should be taken into consideration before paranasal or mastoid surgery to avoid possible complications.

Tinnitus: Does it Lead to Impairments in Metacognitive Functions and the Theory of Mind Skills? - Turkish Archives of Otorhinolaryngology