Maria Serena Chiriacò

Dr. Maria Serena Chiriacò

CNR NANOTEC-Istituto di Nanotecnologia, Via Monteroni, Lecce 73100, Italy
orcid

Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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18 March 2021 in Sensors
Verified
Journal Article
Open access
PDF file
Ilaria BujaIlaria Buja
Ilaria Buja
Erika SabellaErika Sabella
Erika Sabella
Anna Grazia MonteduroAnna Grazia Monteduro
Anna Grazia Monteduro
MCMaria Serena Chiriacò
Maria Serena Chiriacò
Luigi De BellisLuigi De Bellis
Luigi De Bellis
Giuseppe MaruccioGiuseppe Maruccio
Giuseppe Maruccio
Human activities significantly contribute to worldwide spread of phytopathological adversities. Pathogen-related food losses are today responsible for a reduction in quantity and quality of yield and decrease value and financial returns. As a result, “early detection” in combination with “fast, accurate, and cheap” diagnostics have also become the new mantra in plant pathology, especially for emerging diseases or challenging pathogens that spread thanks to asymptomatic individuals with subtle initial symptoms but are then difficult to face. Furthermore, in a globalized market sensitive to epidemics, innovative tools suitable for field-use represent the new frontier with respect to diagnostic laboratories, ensuring that the instruments and techniques used are suitable for the operational contexts. In this framework, portable systems and interconnection with Internet of Things (IoT) play a pivotal role. Here we review innovative diagnostic methods based on nanotechnologies and new perspectives concerning information and communication technology (ICT) in agriculture, resulting in an improvement in agricultural and rural development and in the ability to revolutionize the concept of “preventive actions”, making the difference in fighting against phytopathogens, all over the world.

20 September 2018 in Sensors
Verified
Journal Article
Open access
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MCMaria Serena Chiriacò
Maria Serena Chiriacò
MONICA BIANCOMONICA BIANCO
MONICA BIANCO
ANAnnamaria Nigro
Annamaria Nigro
EPElisabetta Primiceri
Elisabetta Primiceri
Francesco FerraraFrancesco Ferrara
Francesco Ferrara
Giuseppe MaruccioGiuseppe Maruccio
Giuseppe Maruccio
Interest in extracellular vesicles and in particular microvesicles and exosomes, which are constitutively produced by cells, is on the rise for their huge potential as biomarkers in a high number of disorders and pathologies as they are considered as carriers of information among cells, as well as being responsible for the spreading of diseases. Current methods of analysis of microvesicles and exosomes do not fulfill the requirements for their in-depth investigation and the complete exploitation of their diagnostic and prognostic value. Lab-on-chip methods have the potential and capabilities to bridge this gap and the technology is mature enough to provide all the necessary steps for a completely automated analysis of extracellular vesicles in body fluids. In this paper we provide an overview of the biological role of extracellular vesicles, standard biochemical methods of analysis and their limits, and a survey of lab-on-chip methods that are able to meet the needs of a deeper exploitation of these biological entities to drive their use in common clinical practice.

1 May 2020 in Biotechnology Advances
Verified
Journal Article
Closed access
GMGiuseppina Marzano
Giuseppina Marzano
MCMaria Serena Chiriacò
Maria Serena Chiriacò
EPElisabetta Primiceri
Elisabetta Primiceri
MDMaria Elena Dell’aQuila
Maria Elena Dell’aQuila
Joao Ramalho-SantosJoao Ramalho-Santos
Joao Ramalho-Santos
Giuseppe MaruccioGiuseppe Maruccio
Giuseppe Maruccio

24 October 2018 in Sensors
Verified
Journal Article
Open access
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EPElisabetta Primiceri
Elisabetta Primiceri
MCMaria Serena Chiriacò
Maria Serena Chiriacò
FNFrancesca M. Notarangelo
Francesca M. Notarangelo
ACAntonio Crocamo
Antonio Crocamo
DADiego Ardissino
Diego Ardissino
Giuseppe MaruccioGiuseppe Maruccio
Giuseppe Maruccio
A major trend in biomedical engineering is the development of reliable, self-contained point-of-care (POC) devices for diagnostics and in-field assays. The new generation of such platforms increasingly addresses the clinical and environmental needs. Moreover, they are becoming more and more integrated with everyday objects, such as smartphones, and their spread among unskilled common people, has the power to improve the quality of life, both in the developed world and in low-resource settings. The future success of these tools will depend on the integration of the relevant key enabling technologies on an industrial scale (microfluidics with microelectronics, highly sensitive detection methods and low-cost materials for easy-to-use tools). Here, recent advances and perspectives will be reviewed across the large spectrum of their applications.

3 December 2010 in Lab on a Chip
Verified
Journal Article
Closed access
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MCMaria Serena Chiriacò
Maria Serena Chiriacò
EPElisabetta Primiceri
Elisabetta Primiceri
EDEliana D'AMone
Eliana D'AMone
Rodica Elena IonescuRodica Elena Ionescu
Rodica Elena Ionescu
Rosaria RinaldiRosaria Rinaldi
Rosaria Rinaldi
Giuseppe MaruccioGiuseppe Maruccio
Giuseppe Maruccio
A flow-injection impedimetric immunosensor for the sensitive, direct and label-free detection of cholera toxin is reported. A limit of detection smaller than 10 pM was achieved, a value thousands of times lower than the lethal dose. The developed chips fulfil the requirement of low cost and quick reply of the assay and are expected to enable field screening, prompt diagnosis and medical intervention without the need of specialized personnel and expensive equipment, a perspective of special relevance for use in developing countries. Since the chip layout includes two sensing areas each one with a 2 × 2 sensor array, our biochips can allow statistical or (alternatively) multiplex analysis of biorecognition events between antibodies immobilized on each working electrode and different antigens flowing into the chamber.

23 November 2018 in Electronics
Verified
Journal Article
Open access
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MCMaria Serena Chiriacò
Maria Serena Chiriacò
IPIlaria Parlangeli
Ilaria Parlangeli
FSFausto Sirsi
Fausto Sirsi
Palmiro PoltronieriPalmiro Poltronieri
Palmiro Poltronieri
EPElisabetta Primiceri
Elisabetta Primiceri
A great improvement in food safety and quality controls worldwide has been achieved through the development of biosensing platforms. Foodborne pathogens continue to cause serious outbreaks, due to the ingestion of contaminated food. The development of new, sensitive, portable, high-throughput, and automated platforms is a primary objective to allow detection of pathogens and their toxins in foods. Listeria monocytogenes is one common foodborne pathogen. Major outbreaks of listeriosis have been caused by a variety of foods, including milk, soft cheeses, meat, fermented sausages, poultry, seafood and vegetable products. Due to its high sensitivity and easy setup, electrochemical impedance spectroscopy (EIS) has been extensively applied for biosensor fabrication and in particular in the field of microbiology as a mean to detect and quantify foodborne bacteria. Here we describe a miniaturized, portable EIS platform consisting of a microfluidic device with EIS sensors for the detection of L. monocytogenes in milk samples, connected to a portable impedance analyzer for on-field application in clinical and food diagnostics, but also for biosecurity purposes. To achieve this goal microelectrodes were functionalized with antibodies specific for L. monocytogenes. The binding and detection of L. monocytogenes was achieved in the range 2.2 × 103 cfu/mL to 1 × 102 with a Limit of Detection (LoD) of 5.5 cfu/mL.