In Central Africa, groundwater remains the least understood component of the water cycle. Isotopic techniques that are well known to be efficient in tracking the movement of water along its path have been applied for only three decades and can be summarized in a handful of case studies. This review aims to put together all the stable and radioactive isotopic data (>500 samples from rainfall, surface and groundwater) published in Cameroon to: (i) identify the drivers responsible for precipitation isotopes’ spatial variation and climatological implications, (ii) elucidate the groundwater recharge mechanisms over the countries and relationships with rivers, and (iii) highlight the existence of paleo-groundwater in the country. It is found that rainfall stable isotope variation is linked to the migration of the Intertropical Convergence Zone (ITCZ): the groundwater recharge can be diffuse and focused. This latter mechanism is mainly observed in the semi-arid region. It is in this relatively dry region that most of the paleo-groundwater resources are identified thanks to ¹⁴C dating. This information will be useful to develop water management strategies regarding all the challenges (e.g., climatic and demographic) faced by the country. Finally, this paper discusses the gaps groundwater isotope hydrology can still fill for contributing to a sustainable development of the country.

A multi-tracer approach has been implemented in the southwestern part of the Lake Chad Basin to depict the functioning of aquifers in terms of recharge, relationship with surface water bodies, flow paths and contamination. The results are of interest for sustainable water management in the region. The multi-layered structure of the regional aquifer was highlighted with shallower and intermediate to deep flow paths. The shallower aquifer is recharged with rainwater and interconnected with surface water. The groundwater chemistry indicates geogenic influences in addition to a strong anthropogenic fingerprint. The intermediate to deep aquifer shows a longer residence time of groundwater, less connection with the surface and no to only a little anthropogenic influence. Ambient Background Levels (ABLs) and Threshold Values (TVs) show the qualitative status of the groundwater bodies and provide helpful information for water resources protection and the implementation of new directives for efficient and more sustainable groundwater exploitation.