Intrahepatic cholangiocarcinoma (ICC) is a heterogeneous disease characterized by a dismal prognosis. Various attempts have been made to classify ICC subtypes with varying prognoses, but a consensus has yet to be reached. This systematic review aims to gather relevant data on the multi-omics-based ICC classification. The PubMed, Embase, and Cochrane databases were searched for terms related to ICC and multi-omics analysis. Studies that identified multi-omics-derived ICC subtypes and investigated clinicopathological predictors of long-term outcomes were included. Nine studies, which included 910 patients, were considered eligible. Mean 3- and 5-year overall survival were 25.7% and 19.6%, respectively, for the multi-omics subtypes related to poor prognosis, while they were 70.2% and 63.3%, respectively, for the subtypes linked to a better prognosis. Several negative prognostic factors were identified, such as genes’ expression profile promoting inflammation, mutations in the KRAS gene, advanced tumor stage, and elevated levels of oncological markers. The subtype with worse clinicopathological characteristics was associated with worse survival (Ref.: good prognosis subtype; pooled hazard ratio 2.06, 95%CI 1.67–2.53). Several attempts have been made to classify molecular ICC subtypes, but they have yielded heterogeneous results and need a clear clinical definition. More efforts are required to build a comprehensive classification system that includes both molecular and clinical characteristics before implementation in clinical practice to facilitate decision-making and select patients who may benefit the most from comprehensive molecular profiling in the disease’s earlier stages.

Background: Recent innovations such as robotic platforms and liver venous deprivation (LVD) have the potential to improve the management and surgical treatment of peri-hilar cholangiocarcinoma (Ph-CCA). Robotic platforms integrate the operative field view with intraoperative ultrasound and preoperative 3D planning. ^1–4 LVD is increasingly preferred over portal vein embolization for better liver hypertrophy outcomes in both speed and percentage. ⁵ This video demonstrates the feasibility of fully robotic right hepatectomy with common bile duct resection and reconstruction for Ph-CCA after LVD. Patients: A Bismuth 3a Ph-CCA was diagnosed in a 74-year-old female with jaundice. Preoperatively, the patient underwent 3D volumetry and planning and percutaneous drainage of left biliary ducts. The future remnant liver volume increased from 38 to 53% of total liver volume after LVD. Technique: Four robotic trocars and one laparoscopic port were placed, and the da Vinci Xi system was docked. En-bloc regional lymphadenectomy was performed, followed by isolation of the hepatic pedicle elements. After mobilization of the caudate lobe and section of the distal common bile duct, the en-bloc right hepatectomy was carried out. A single biliodigestive anastomosis was performed on B2-3-4 on an antecolic Roux-&-Y jejunal loop. The operative time was 810 min. The blood loss was 500 mL. The patient was discharged on postoperative day 16. The pathology confirmed pT2b N0 (0/11 nodes) R0r R0b ^6,7 G2 Ph-CCA. Conclusion: Although this was a very demanding and challenging approach for both the patient and the surgical team, this video demonstrates the feasibility of this management and probably sets the goal for a new standard of care.

Robotic surgery is gaining momentum in liver resection due to its three-dimensional (3D) magnified view and articulated instrumentation.1 However, some cri