Denis LE BIHAN

Dr. Denis LE BIHAN

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Academic Career Length

36Years (1991-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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8 August 2006 in Journal of Magnetic Resonance Imaging
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Journal Article
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DBDenis LE BIHAN
Denis LE BIHAN
CPCyril Poupon
Cyril Poupon
AAAlexis Amadon
Alexis Amadon
FLFranck Lethimonnier
Franck Lethimonnier
1 February 2019 in NeuroImage
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Journal Article
Open access
DBDenis LE BIHAN
Denis LE BIHAN
Intravoxel Incoherent Motion (IVIM) refers to translational movements which within a given voxel and during the measurement time present a distribution of speeds in orientation and/or amplitude. The IVIM concept has been used to estimate perfusion in tissues as blood flow in randomly oriented capillaries mimics a pseudo-diffusion process. IVIM-based perfusion MRI, which does not require contrast agents, has gained momentum recently, especially in the field oncology. In this introductory review the basic concepts, models, technical requirements and limitations inherent to IVIM-based perfusion MRI are outlined, as well as new, non-perfusion applications of IVIM MRI, such as virtual MR Elastography.
1 June 2012 in NeuroImage
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Journal Article
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DBDenis LE BIHAN
Denis LE BIHAN
HJHeidi Johansen-Berg
Heidi Johansen-Berg
1 January 2016 in Radiology
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Journal Article
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Mami IimaMami Iima
Mami Iima
DBDenis LE BIHAN
Denis LE BIHAN
Intravoxel incoherent motion and non-Gaussian diffusion MR imaging have the potential to give a semi-automatic diagnosis of lesions with high accuracy without using ionizing radiation and injection of radioisotopes or contrast agents. The concept of diffusion magnetic resonance (MR) imaging emerged in the mid-1980s, together with the first images of water diffusion in the human brain, as a way to probe tissue structure at a microscopic scale, although the images were acquired at a millimetric scale. Since then, diffusion MR imaging has become a pillar of modern clinical imaging. Diffusion MR imaging has mainly been used to investigate neurologic disorders. A dramatic application of diffusion MR imaging has been acute brain ischemia, providing patients with the opportunity to receive suitable treatment at a stage when brain tissue might still be salvageable, thus avoiding terrible handicaps. On the other hand, it was found that water diffusion is anisotropic in white matter, because axon membranes limit molecular movement perpendicularly to the nerve fibers. This feature can be exploited to produce stunning maps of the orientation in space of the white matter tracts and brain connections in just a few minutes. Diffusion MR imaging is no...
1 August 2013 in Radiology
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DBDenis LE BIHAN
Denis LE BIHAN
9 March 2007 in Physics in Medicine & Biology
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DBDenis LE BIHAN
Denis LE BIHAN
Functional neuroimaging has emerged as an important approach to study the brain and the mind. Surprisingly, although they are based on radically different physical approaches both positron emission tomography (PET) and magnetic resonance imaging (MRI) make brain activation imaging possible through measurements involving water molecules. So far, PET and MRI functional imaging have relied on the principle that neuronal activation and blood flow are coupled through metabolism. However, a new paradigm has emerged to look at brain activity through the observation with MRI of the molecular diffusion of water. In contrast with the former approaches diffusion MRI has the potential to reveal changes in the intrinsic water physical properties during brain activation, which could be more intimately linked to the neuronal activation mechanisms and lead to an improved spatial and temporal resolution. However, this link has yet to be fully confirmed and understood. To shed light on the possible relationship between water and brain activation, this introductory paper reviews the most recent data on the physical properties of water and on the status of water in biological tissues, and evaluates their relevance to brain diffusion MRI. The biophysical mechanisms of brain activation are then reassessed to reveal their intimacy with the physical properties of water, which may come to be regarded as the 'molecule of the mind'.