The expression of GPCRs has been associated with schizophrenia, and their expression may induce morphological changes in brain regions responsible for schizophrenia and disease-specific behavioral changes. The articles included in this review were selected using keywords and databases of scientific research websites. The expressions of GPRs have different involvements in schizophrenia, some increase the risk while others provide protection, and they may also be potential targets for new treatments. Proper evaluation of these factors is essential to have a better therapeutic response with a lower rate of chronicity and thus improve the long-term prognosis.

Background: Cardiovascular diseases (CVDs) are a leading cause of death globally, with a significant impact on public health and quality of life. In addition to traditional risk factors such as hypertension, diabetes, smoking, and hypercholesterolemia, a growing body of scientific evidence suggests the crucial role of psychosocial factors, including personality, in the development and prognosis of CVDs. In recent decades, researchers have focused on the so-called “type D personality.” Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a literature search was conducted using the PubMed/Medline, Scopus, and Cochrane databases. Fifteen studies were included in the final quantitative analysis, involving 5687 people. The qualitative assessment of the studies included in this meta-analysis was conducted adopting the Quality System Tool. Results: Several studies have shown a significant correlation between type D personality and an increased risk of CVDs, as well as a worse prognosis in patients with established CVDs. The overall quality of the studies included in this synthesis ranged from 0.70 to 0.96, indicating the general good quality levels of the studies (69%). The association between type D personality and CVDs in terms of prevalence underlined a raw proportion of 0.36. Conclusions: This study reinforces the significance of type D personality as a psychological risk factor for CVD, with implications for both disease prevalence and severity.

Objective: This meta-analysis aimed to examine the bidirectional association between PTSD and cardiovascular disease (CVD) by evaluating the following: (1) the risk of increased CVD incidence in individuals with PTSD; and (2) the prevalence of PTSD in patients with cardiovascular disease. Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a literature search was conducted of the PubMed/Medline, Scopus, and Web of Science databases without using a temporal publication range. For the PTSD-to-CVD direction, 18 studies were combined. For the CVD-to-PTSD direction, 11 studies that ascertained the incidence or prevalence of PTSD following a CVD event were combined. Results: The findings confirm the bidirectional and clinically significant relationship between CVD and PTSD. Conclusions: These data underscore the need to integrate trauma-informed approaches into cardiovascular care and stress management into psychiatric treatment to stop this pathological cycle.

Background: Depression is one of the leading causes of disability worldwide, with a significant impact on individuals’ quality of life. The use of antidepressants is fundamental in the treatment of this condition; however, it is essential to recognize that the use of these drugs can be associated with adverse effects, including cardiotoxicity. Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a literature search was conducted of the PubMed/Medline, Scopus, and Cochrane databases. Twenty studies were included in the final quantitative analysis. The Joanna Briggs Institute critical appraisal tool was used to assess the risk of bias. Results: It is possible to highlight a correlation between intake of antidepressants and development of cardiotoxicity. Analysis of the selected studies allows for an understanding of the importance of a multidisciplinary approach for the protection of these patients. Conclusions: Management of antidepressant-induced cardiotoxicity requires a thorough understanding of the pathophysiological mechanisms involved and a critical evaluation of the various therapeutic strategies available to promote clinical practice.

Background and Objectives: Evidence regarding how dispositional traits, antenatal anxiety, substance use, and obstetric events converge to shape post-partum depression (PPD) in South-East Europe is limited. We analysed 102 third-trimester women and followed them to six weeks post-partum, and 102 age-matched community controls were used to (i) compare baseline psychological profiles, (ii) chart antenatal-to-post-partum symptom trajectories, and (iii) build an integrated model of clinically relevant PPD (Edinburgh Post-natal Depression Scale, EPDS ≥ 12). Materials and Methods: All 96 raw variables were forward–backward translated from Romanian, reconciled, and harmonized. The principal instruments used were EPDS, State–Trait Anxiety Inventory form Y (STAI-Y), Revised Obsessive–Compulsive Inventory (OCI-R), NEO Five-Factor Inventory (NEO-FFI-60), and the four-item Maternal Worry and Satisfaction Scale (MWSS). Results: Groups were age-matched (31.1 ± 5.4 vs. 30.3 ± 5.1 years, p = 0.268) but differed in urban residence (39% vs. 17%, p = 0.001) and current substance use (smoking 21% vs. 34%, p = 0.041; alcohol 6% vs. 22%, p = 0.002). Of five personality domains, only openness scored lower in peripartum women (26.1 ± 4.6 vs. 29.3 ± 5.2, p < 0.001). State anxiety rose significantly from pregnancy to puerperium (+5.1 ± 8.4 points, p < 0.001). Post-partum EPDS correlated most strongly with state anxiety (r = 0.62) and neuroticism (r = 0.50). A final model (pseudo-R² = 0.30) identified post-partum state anxiety (OR 1.10 per point, 95% CI 1.05–1.15, p < 0.001) as the independent predictor; neuroticism showed a trend (OR 1.08, p = 0.081). Obstetric factors (prematurity, birth weight, caesarean section) were not significant. Conclusions: In this Romanian cohort, heightened state anxiety—in synergy with high neuroticism and lower openness—dominated the risk landscape of early onset PPD, whereas delivery mode and neonatal status were neutral. Routine perinatal mental health screening should therefore incorporate anxiety metrics alongside depression scales and brief trait inventories to refine preventive targeting.