Extensive studies have demonstrated that oxidative stress plays a vital role in the pathology of several neurological diseases, including autism spectrum disorder (ASD); those studies proposed that GSH and antioxidant enzymes have a pathophysiological role in autism. Furthermore, camel milk has emerged to have potential therapeutic effects in autism. The aim of the current study was to evaluate the effect of camel milk consumption on oxidative stress biomarkers in autistic children, by measuring the plasma levels of glutathione, superoxide dismutase, and myeloperoxidase before and 2 weeks after camel milk consumption, using the ELISA technique. All measured parameters exhibited significant increase after camel milk consumption (). These findings suggest that camel milk could play an important role in decreasing oxidative stress by alteration of antioxidant enzymes and nonenzymatic antioxidant molecules levels, as well as the improvement of autistic behaviour as demonstrated by the improved Childhood Autism Rating Scale (CARS).

According to previous research, individuals with autism spectrum disorder (ASD) have lower levels of physical activity than their typically developed (TD) counterparts. There have been conflicting reports about physical activity (PA) levels in people with ASD. Given the conflicting evidence, further investigation is required. We believe that evaluating PA in individuals with ASD is critical in order to offer PA intervention plans aiming at increasing their health-related physical fitness on a daily, systematic, and individualized basis. In the current study, an ActiGraph monitor (GT3X+) was used to accurately measure PA and sedentary activity in 21 children with autism aged 6.43 ± 2.29 years and 30 TD children aged 7.2 ± 3.14 years. Our data indicated that while the light and moderate activity counts were not significantly different between the two groups, the vigorous activity was significantly higher in ASD compared to TD. This finding was attributed to ASD characteristic stereotypy and self-stimulating behaviors. The significantly higher vigorous PA is discussed in relation to altered neurochemistry, oxidative stress, and neuroinflammation as etiological mechanisms in ASD. This research provides a better understanding of the status of PA participation in individuals with ASD.

Background and Study Aim. Physical exercise is linked with several physical and psychological health advantages. A range of investigations has revealed the presence of a significant association between physical exercise and indicative improvements in subjects with Autism Spectrum Disorder (ASD). This systematic review aims to update the literature about the impact of physical exercise interventions on social, behavioral, and other outcomes for individuals with ASD. Materials and Methods. The study design followed the PRISMA guidelines. A systematic search of electronic databases—PubMed, Google Scholar, Science Direct, and Jane Publications—was performed from 2010 to December 2023. We searched for related research papers in English using keywords 'Autism Spectrum Disorder,' 'exercise,' and 'physical activity. Results. This systematic review employed a four-stage screening process, which resulted in the inclusion of 18 trial studies. The intervention period varied from three to forty-eight weeks, with a frequency of 3-7 times per week. The results demonstrated that physical exercise had a substantial positive impact on communication, social interaction, and motor skills in subjects with Autism Spectrum Disorder (ASD). Conclusions. This review supports physical exercise as a powerful tool in decreasing stereotypical behaviors, and in improving social communication and motor skills in subjects diagnosed with ASD. Regular physical exercise therapy can have a greater effect on improving the quality of life for ASD subjects.

Background: Increasing evidence indicates that skin disorders may contribute to an increased risk of autism spectrum disorder (ASD). They can affect the quality of life, and they have an impact on social isolation, behavioral problems, cognitive scores, and some subscales of ASD. Methods: This study was an online questionnaire-based, observational, and cross-sectional study conducted during the period from August 2022 through January 2023 to examine dermatological manifestations among ASD individuals compared to controls. Descriptive and non-parametric tests were used for data analysis. Results: A total of 363 individuals with skin diseases were interviewed during the study period. In total, 189 (52.1%) of participants were autistic and 174 (47.9%) were controls. Asthma, anxiety, depression, and autoimmune disease were persistent in the ASD group compared to the controls (p < 0.001). The results also show that skin, food, and respiratory allergies were statistically significantly associated with ASD (50%, 22.2%, 14.8%, respectively) compared to the controls (26.4%, 10.3%, 7.5%, respectively) (p < 0.05). The most prevalent disease in the controls was eczema (15.5%), followed by dry skin (14.9%) and acne (10.3%). These diseases showed a statistically significant association with ASD compared to the controls (p < 0.0001). Conclusions: Our findings indicate that atopic disorders and comorbidities, including eczema, asthma, and allergies, are significantly associated with ASD. A large population-based study is warranted to clarify the prevalence of skin disorders among individuals with ASD, coupled with the study of the association between skin disorders and comorbidities to determine the relationship precisely.

Background: Autism spectrum disorder (ASD) is a condition related to neurodevelopment, typically identified by impaired social interactions and repetitive stereotypical behaviors. The etiology of ASD is not well known, but neuroplasticity has been suggested to play a pathological role. A disintegrin and metalloproteinases (ADAMs) are multifunctional transmembrane proteins that are important for development, communication, and plasticity in the nervous system. This study aimed to determine the correlations among ADAM proteins (ADAM-8, 10, 17, and 22) in children with ASD and to discuss their potential roles as molecular contributors to processes underlying neuroplasticity. Methods: The Spearman correlation coefficient (r) between plasma levels of ADAM 8, 10, 17, and 22 in children with ASD (n = 40) was obtained using the Statistical Package for the Social Sciences software, SPSS. Results: A significant correlation was obtained between plasma levels of the ADAM 8 and ADAM-17 (r = 0.523, p ≤ 0.001); ADAM 8 and ADAM 22 (r = 0.576, p ≤ 0.001); and ADAM 17 and ADAM 22 (r = 0.489, p ≤ 0.001). However, no significant correlation between ADAM 10 and ADAM 8 (r = −0.147, p = 0.372); ADAM-17 (r = −0.143, p = 0.378), and ADAM-22 (r = −0.066, p = 0.684), was obtained. Conclusions: This study provides the first evidence of associations among circulating ADAM proteins (ADAM-8, ADAM-17, and ADAM-22) in children with ASD, suggesting their potential molecular involvement in pathways related to neuroplasticity. Further studies with larger cohorts and direct neuroplasticity measures are needed to clarify these relationships and their relevance to ASD pathophysiology.