The research work conducted mainly on the reduction reaction of NO x , the oxidation reaction of CO, and hydrocarbons, electro‐catalysis of oxygen in alkaline medium, and photocatalytic water splitting has proved excellent catalytic behavior of perovskite oxides. [16–23] Although only a few reports published usages of the perovskite oxides as catalysts for the organic transformation such as catalytic hydrogenation, Ullmann, Sonogashira reactions, and Suzuki couplings. [24–26] Yoon et al. have prepared K 2 CO 3 based LaMn 1‐x Cu x O 3 perovskite oxide as a potential catalyst and discussed their mechanistic aspects in various reactions occurring at room temperature. [27] Recently, Wu and Ajayan group has demonstrated the relationship between stoichiometry and activity of pure and B‐site substituted layered perovskite oxide in the decomposition reaction of isopropanol by considering Sr 2 Sn 1‐x Ru x O 4 (0≤x≤1) as catalyst. [28] In this scenario, present work aims to summarize the contribution of perovskite oxides as catalyst in numerous organic syntheses and catalysis, photocatalysis, and electrocatalysis reactions.
Cancer, the biggest cause of death globally, remains a tough illness despite enormous advances in therapy. In the present study, 1,3-benzodioxole-tagged dacarbazine derivates were investigated as microtubule inhibitors in order to control cancer as microtubules are involved in cell proliferation. The tubulin protein was analyzed and its structure was validated by various protein validation tools. The binding potential of 1,3-benzodioxole-based dacarbazine-tagged derivatives with tubulin was checked using molecular docking software HEX 8.0 CUDA and AutoDock Vina. Swiss ADME online Web server and pkCSM are used for studying pharmacokinetic and pharmacological studies of compounds. The docking analysis ADME studies displayed that Compounds 1 and 2 bind effectively with the tubulin protein and showed potential properties to use as a potent anticancer drug.