Hyperglycemia and inflammation are hallmarks of the prediabetes stage, which has the potential to develop into diabetes mellitus. In this stage, lifestyle changes and exercise are recommended and have been shown to be effective. However, there has been insufficient study investigating the impact of Ruesi Dadton (RD) exercise on prediabetes. Therefore, this study aimed to investigate the effect of RD exercise on biomarkers of glycemic level including fasting plasma glucose (FPG), the 2 h oral glucose tolerance test (OGTT), hemoglobin A1C (HbA1C), the biomarkers of inflammation C-reactive protein (CRP) and interleukin 6 (IL-6), and body mass index (BMI) on prediabetes during 12-week RD exercise. A total of 64 participants were randomly assigned into two groups, RD and control (CON), and were tested by measuring their glycemic levels to screen for prediabetes. The RD group was instructed to perform 10 postures of RD exercise in 60 min, three times a week. The CON group received standard lifestyle recommendations that were not pharmacologically managed. The results reveal that the RD group experienced a significant decrease in FPG, OGTT, HbA1C, and IL-6 (p < 0.01), and BMI and CRP (p < 0.05) compared to the CON group. In addition, the CON group had considerably higher glycemic levels, BMI and IL-6 levels (p < 0.01). Our study demonstrates that RD could decrease the biomarkers of glycemic level and inflammation during 12 weeks of RD exercise in prediabetes. These findings suggest that RD exercise is an effective approach for reducing systemic inflammation and controlling glycemic levels in prediabetic patients.

Uric acid is closely related to diseases such as gout, kidney failure, and metabolic disorders. A conventional method for measuring uric acid over 24 h is time intensive and cumbersome for patients who have to take samples to the hospital. At present, hospitals use only laboratory instruments to determine 24-h uric acid concentrations in the urine. This study presents the proof-of-concept of a portable point-of-care tool called Uricia, designed to improve the quality of life of patients monitoring uric acid. Spectrophotometry was performed at a fixed wavelength of 295 nm. The urine sample contained within the cuvette absorbs ultraviolet light, with uric acid specifically responsible for this absorption, thereby allowing the device to measure its concentration. An internal calibration algorithm was used to accommodate the nonlinear optical response of Uricia and was calibrated to a benchtop GENESYS 10S UV–Vis spectrophotometer. The experiments further evaluated potential urinary interferences, revealing that while most constituents had minimal impact, ascorbic acid demonstrated the highest interference, contributing up to 15% of the total signal at high physiological concentrations. This device and the corresponding spectrophotometry method revealed that high concentrations of uric acid precipitated insoluble crystals. A dilution set to an alkali solution vial to be premixed and dissolve the uric acid crystals was added, increasing the detection window to 10 mg/dL, with an LOD of 0.0232 mg/dL and LOQ of 0.0702 mg/dL. Cloud-based data measurement enables spot analysis, which is meant to provide insight into patient status development. These results validated the technical architecture of a controlled matrix for measuring uric acid.

Background: Less breast milk, breast pain, and engorgement are issues that the majority of postpartum mothers have to confront and overcome. Objective: This study examined the efficacy of Manual Lymphatic Drainage (MLD), Thai Traditional Massage (TTM), and standard post-partum nursing care on breast milk volume, breast pain, and engorgement in post-cesarean mothers of preterm infants. Methods: Thirty-two participants were randomly divided into 2 groups: an intervention group receiving MLD, TTM, and standard post-partum nursing care (n=16), and a control group receiving standard post-partum nursing care alone (n=16). Outcomes were assessed through breast milk volume, breast pain and engorgement scores, and participant satisfaction. Results: The study showed that the group receiving MLD, TTM, and standard post-partum nursing care had a safe and equivalent level of breast milk production compared to the control group. Additionally, there were no significant differences between groups regarding daily milk expression frequency, breast pain, and engorgement over seven days (p>0.05). However, the experimental group expressed a high level of satisfaction with the MLD, TTM, and standard post-partum nursing care interventions. Conclusion: The combination of MLD, TTM, and standard post-partum nursing care could be a viable alternative for managing post-cesarean care in mothers with preterm infants. Clinical Trial Reg Number: TCTR20230330002.

Etoricoxib, a commonly prescribed non-steroidal anti-inflammatory drug (NSAID), has been associated with adverse cutaneous reactions, including fixed drug eruption (FDE). We describe a case report of a 37-year-old Thai male who developed erythematous plaques and bullous lesions following the ingestion of a 90 mg dose of Etoricoxib. The lesions were located on the lateral aspect of the right leg near the popliteal fossa, the dorsal aspect of the right foot, the medial aspect of the right arm, and the left lumbar region. Symptoms began two hours post-ingestion with pruritus, progressing to erythema and bullous formation over the subsequent 72 h. The patient was treated with oral Prednisolone, antihistamines, and topical steroids, resulting in significant clinical improvement within 12 days. This case highlights the potential of Etoricoxib to trigger generalized bullous fixed drug eruption (GBFDE), which is a more severe variant involving more than three body sites and classified as one of the Severe Cutaneous Adverse Reactions (SCARs), emphasizing the need for prompt recognition and appropriate management to prevent recurrence and mitigate symptoms.

This cross-sectional analytical study involved consecutive

Purpose: This study investigated the effect of low to moderate Thai exercise training (Ruesi Dadton) compared to standard self-care on lipid profiles and physical performance in overweight individuals.Methods: Sixty-one participants were randomly assigned to either an intervention group, which practised Ruesi Dadton exercises for 60 minutes, three times per week for 12 weeks under the supervision of a Thai Traditional Medicine (TTM) Practitioner via an online platform, or a control group, which received guidance on self-care for managing hyperlipidaemia.Results: The intervention group demonstrated a decreasing trend in total cholesterol (TC) and a significant reduction in LDL cholesterol (LDL) levels, from 141.52 ± 32.29 to 125.68 ± 26.74 mg/dL (p < 0.05). In contrast, LDL levels increased in the control group (p < 0.05). Additionally, the intervention group showed improvements in physical performance (p < 0.05) and anthropometric indices (p < 0.05), while the control group experienced a decrease in these outcomes. Regarding quality of life, both groups showed significant improvement (p< 0.05).Conclusions: It could be concluded that low to moderate Ruesi Dadton effectively manages and reduces blood lipid levels and positively impacts physical performance, anthropometric indices, and quality of life.