Background/Objectives: Transmission electron microscopy (TEM) is an essential tool for diagnosing renal diseases. It produces high-resolution visualization of glomerular and mesangial ultrastructural features. However, manual interpretation of TEM images is labor-intensive and prone to interobserver variability. In this study, we introduced and evaluated deep learning architectures based on YOLOv8-OBB for automated detection of six ultrastructural features in kidney biopsy TEM images: glomerular basement membrane, mesangial folds, mesangial deposits, normal podocytes, podocytopathy, and subepithelial deposits. Methods: Building on our previous work, we propose a modified YOLOv8-OBB architecture that incorporates three major refinements: a grayscale input channel, a high-resolution P2 feature pyramid with refinement blocks (FPRbl), and a four-branch oriented detection head designed to detect small-to-large structures at multiple image scales (feature-map strides of 4, 8, 16, and 32 pixels). We compared two pretrained variants: our previous YOLOv8-OBB model developed with a grayscale input channel (GSch) and four additional feature-extraction layers (4FExL) (Pretrained + GSch + 4FExL) and the newly developed (Pretrained + FPRbl). Results: Quantitative assessment showed that our previously developed model (Pretrained + GSch + 4FExL) achieved an F1-score of 0.93 and mAP@0.5 of 0.953, while the (Pretrained + FPRbl) model developed in this study achieved an F1-score of 0.92 and mAP@0.5 of 0.941, demonstrating strong and clinically meaningful performance for both approaches. Qualitative assessment based on expert visual inspection of predicted bounding boxes revealed complementary strengths: (Pretrained + GSch + 4FExL) exhibited higher recall for subtle or infrequent findings, whereas (Pretrained + FPRbl) produced cleaner bounding boxes with higher-confidence predictions. Conclusions: This study presents how targeted architectural refinements in YOLOv8-OBB can enhance the detection of small, low-contrast, and variably oriented ultrastructural features in renal TEM images. Evaluating these refinements and translating them into a web-based platform (Renal-AI) showed the clinical applicability of deep learning-based tools for improving diagnostic efficiency and reducing interpretive variability in kidney pathology.

Faculty governance in higher education depends on transparent participation, reliable quorum enforcement, accountable record keeping, and strict alignment with institutional regulations. Conventional departmental council processes provide formal authority and academic deliberation, but they often rely on manual documentation, fragmented records, and procedural enforcement that is difficult to verify after the fact. This work presents an integrated hybrid Decentralized Autonomous Organization (DAO) framework for faculty governance that combines regulatory alignment analysis, a working smart-contract prototype, and scenario-based simulation. The framework is designed for university departmental councils and is structured across three layers: off-chain community governance, on-chain protocol governance, and off-chain execution governance. It expands prior conceptual work by incorporating governance dimensions related to roles, incentives, membership, communication, decision-making, identity, auditability, conflict-of-interest handling, and institutional ratification. The evaluation simulates 1488 proposals across twelve scenarios covering four faculty sizes (15, 30, 50, and 100 members) and three adoption levels (low, moderate, and high). Scenario results indicate that adoption intensity is the dominant driver of governance performance: mean participation increases from about 33% under low usage to about 85% under high usage, quorum achievement rises from about 6% to about 96%, and execution rises from about 19% to about 70%. Relative to a modeled conventional workflow baseline, the DAO-supported process reduces decision-cycle time by about 76%, improves audit completeness by about 30%, and increases traceability from about 0.63 to 1.00. The results indicate that DAO-assisted faculty governance can strengthen transparency, procedural consistency, and auditability while preserving legally mandated university authority, but its practical value depends on sustained participation, privacy safeguards, cost control, and clearly defined hybrid control points.