Shadi A. Esfahani is a diagnostic radiologist and nuclear medicine physician at Massachusetts General Hospital. She has a strong clinical and research training background in molecular imaging and the treatment of cancer. Her efforts have been integral in the design, preclinical application, and translation of positron emission tomography (PET), magnetic resonance imaging (MRI), and optical molecular imaging and radiotherapeutic probes that target receptors, tumor microenvironment components, and metabolic pathways, among others, particularly in gastrointestinal malignancies. As the director of clinical trials in nuclear medicine, Dr. Esfahani has led multiple clinical trials to translate molecularly targeted radiopharmaceuticals for the better care of cancer patients.