Starting from a reformulation of the mass balance law based on the Bilby–Kröner–Lee (BKL) decomposition of the deformation gradient tensor, we study some peculiar mechanical aspects of growth in a monophasic continuum by regarding the reformulated mass balance equation as a non-holonomic and rheonomic constraint. Such constraint restricts the admissible rates of the growth tensor, i.e., one of the two factors of the BKL decomposition, to comply with a growth law provided phenomenologically. For our purposes, we put the constraint in Pfaffian form, and treat time as a fictitious, additional Lagrangian parameter, subjected to the condition that its rate must be unitary. Then, by taking some suggestions from the literature, we assume the existence of generalized forces conjugated with the virtual variations of the growth tensor, and we write a constrained version of the Principle of Virtual Work (PVW) that leads to a mixed boundary value problem whose unknowns are the motion, the growth tensor, and the Lagrange multipliers of the considered theory. This allows to extrapolate a physical interpretation of the role that the growth-conjugated forces play on the components of the growth tensor, especially on the distortional ones, i.e., those that are not directly related to the variation of mass of the body. The core message of our work is conceptual: we show that the growth laws usually encountered in the literature, which are prescribed phenomenologically, but may be difficult to justify theoretically, can be put in the framework of the PVW by regarding them as constraints. Moreover, we retrieve more particularized frameworks of growth available in the literature, while being able to switch to a theory of growth of grade one, such as a Cahn–Hilliard model of growth.

The motion of the interstitial uid of a biological tissue is studied by employing the Darcy-Forchheimer law, a correction to standard Darcy's law. The tissue is modelled as a saturated biphasic medium comprising the fluid and a deformable matrix. The reason for undertaking this study is that a description of the tissue's dynamics based on the Darcy-Forchheimer law might be more complete than the one based on Darcy's law, since the former provides a better macroscopic representation of the microscopic fluid-solid interactions. Through numerical simulations, we analyse the influence of the Forchheimer's correction.