Reports on recurrence and outcomes of US patients with gastric cancer are scarce. The aim of this study was to determine incidence and pattern of recurrence after curative intent surgery for gastric cancer. Using the multi-institutional US Gastric Cancer Collaborative database, we identified 817 patients undergoing curative intent resection for gastric cancer between 2000 and 2012. Patterns and rates of recurrence along with associated risk factors were identified using adjusted regression analysis. Recurrences were classified as locoregional, peritoneal, or hematogenous. Median patient age was 65.8 years (interquartile range [IQR] 56.4, 74.7); the majority of patients were male (n = 462, 56.6%) and white (n = 511, 62.5%). At the time of surgery, the majority of patients underwent a partial gastrectomy (n = 481, 59.2%) with a complete R0 resection achieved in 91.6% (n = 748) of patients. At the time of last follow-up, 244 (29.9%) of 817 patients developed a recurrence; 163 (66.8%) patients had recurrence at only a single site; the remaining 81 (33.2%) had multiple sites of initial recurrence. Among patients who recurred at a single site, recurrence was most common at a distant location and included hematogenous (n = 57, 23.4%) or peritoneal (n = 47, 19.3%) only metastasis. Tumors at the gastroesophageal junction (odds ratio [OR] 3.18, 95% CI 1.08 to 9.40; p = 0.04) were associated with higher risk of locoregional recurrence, while the presence of multiple lesions (OR 10.82, 95% CI 3.56 to 32.85; p < 0.001) remained associated with an increased risk of distant hematogenous recurrence after adjusted analysis. Recurrence was associated with worse survival, with a median recurrence-free survival of 10.8 months (IQR 8.9, 12.8) among those who experienced a recurrence. Nearly one-third of patients experienced recurrence after gastric cancer surgery. The most common site of recurrence was distant.

Surgical therapy, often combined with adjuvant systemic chemotherapy, is the best therapeutic option to treat patients with colorectal liver metastasis (CRLM), with postoperative 5-year survival ranging from 40% to 50%.^1,2 However, while overall survival (OS) has improved, many patients with CRLM will recur and ultimately die of their disease.^1,3 The factors used to predict outcome following surgical resection of CRLM largely focus on clinicopathological prognostic factors such as preoperative carcinoembryonic antigen (CEA) level, presentation of disease (ie, synchronous vs metachronous disease), disease-free interval between primary tumor and hepatic metastasis, and metastatic tumor number and size.⁴ There has been increasing interest in the use of biologic and molecular markers in the prognostic assessment of patients with metastatic colorectal cancer undergoing liver resection.⁴ Among patients with colorectal adenocarcinoma, mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most common oncogene of the RAS family, reported in up to 30% to 40% of patients.^5-9 While the frequency and prognostic impact of KRAS mutation status have been described for both primary and metastatic colorectal cancer, to our knowledge, the role of specific mutations on KRAS codons remains undefined.^10-14

The efficacy of neoadjuvant therapy (NT) versus surgery first (SF) for pancreatic ductal adenocarcinoma (PDAC) remains controversial. A random-effects meta-analysis of only prospective randomized controlled trials (RCTs) comparing NT versus SF for potentially resectable (PR) or borderline resectable (BR) PDAC was performed. Among six RCTs including 850 patients, 411 (48.3%) received NT and 439 (51.6%) SF. In all included trials, NT was gemcitabine-based: four using chemoradiation and two chemotherapy alone. Based on an intention-to-treat analysis, NT resulted in improved overall survival (OS) compared to SF (HR 0.73, 95% CI 0.61–0.86). This effect was independent of anatomic classification (PR: hazard ratio (HR) 0.73, 95% CI 0.59–0.91; BR: HR 0.51 95% CI 0.28–0.93) or NT type (chemoradiation: HR 0.77, 95% CI 0.61–0.98; chemotherapy alone: HR 0.68, 95% CI 0.54–0.87). Overall resection rate was similar (risk ratio (RR) 0.93, 95% CI 0.82–1.04, I² = 39.0%) but NT increased the likelihood of a margin-negative (R0) resection (RR 1.51, 95% CI 1.18–1.93, I² = 0%) and having negative lymph nodes (RR 2.07, 95% CI 1.47–2.91, I² = 12.3%). In this meta-analysis of prospective RCTs, NT significantly improved OS in an intention-to-treat fashion, compared with SF for localized PDAC. Randomized controlled trials using contemporary multi-agent chemotherapy will be needed to confirm these findings and to define the optimal NT regimen.