The Vietnamese Mekong Delta (VMD) is a low-lying region and one of the largest economic centers in southern Vietnam, with a population of approximately 18 million people. Groundwater is a crucial resource in the region, serving essential functions in domestic, agricultural, and industrial domains.Due to increasing surface water pollution and salinization, its importance has been increasing. The geological composition of the region includes seven sedimentary aquifers: Holocene (qh), Middle-Pleistocene (qp3, qp2-3, qp1), Pliocene (n22, n21), and Upper-Miocene (n13). The lower confined aquifer system contains non-renewable groundwater that was replenished during the last sea level low stand. Unfortunately, the intensive extraction of groundwater has led to several negative impacts, including declining groundwater levels, saline intrusion and the potential threat of land subsidence in various locations. This is especially concerning due to the low elevation and low hydraulic gradient of the delta.This study quantitatively the future changes in groundwater level in the VMD using a FEFLOW variable density flow and transport model, considering various climate change and groundwater exploitation scenarios. The results reveal a significant decline in groundwater levels by the year 2100: 15-25 m in the aquifers qp2-3, qp3, n22, n21, n13 and more than 35 m in the aquifer qp1 under the . The model results also showed the varying degrees of ongoing saline intrusion observed in both the Pleistocene (qp) and Neogene (n) aquifers, resulting from increased hydraulic gradients near the cones of depression and draining of saline paleo-groundwater from aquitards. To mitigate the risks associated with saltwater intrusion, it is recommended to strategically plan the placement of groundwater extraction wells at a considerable distance from the local saline boundary.To decrease the demand for groundwater and slow down the decline in groundwater levels and subsequent land subsidence rates, it is advisable to implement measures such as (a) managed aquifer recharge, (b) the development of additional water sources like rainwater harvesting and desalination, and (c) the promotion of surface water treatment and utilization, especially in regions experiencing water scarcity. To assess the potential for managed aquifer recharge, an aquifer storage and recovery (ASR) pilot project was implemented, recharging highly-treated surface water by gravity into two different confined aquifers. The results showed a considerable absorption capacity for both aquifers. Based on the recovery efficiency, ASR seems to be a feasible option for slightly brackish aquifers, but is not recommended for saline aquifers. For the upscaling of MAR, site feasibility must be assessed based mainly on water source availability and quality, as well as cost-benefit considerations.Keywords: Mekong Delta, Groundwater Modelling, saltwater intrusion, Vietnam, FEFLOW, Managed Aquifer Recharge