Macadamia decline poses a serious economic threat to the macadamia industry. It exhibits either a slow decline due to infection by Kretzschmaria clavus or Ganoderma lucidum, or a quick decline caused by pathogens like Phytophthora spp., Lasiodiplodia spp., Neofusiccocum spp., Nectria rugulosa, Xylaria arbuscula, Phellinus gilvus, Acremonium recifei, and Rosellinia spp. Chemical strategies, resistant cultivars, and agronomic measures have been widely adopted to control macadamia decline, but effective biological control measures have rarely been applied. This paper proposes two key steps for implementing biological control strategies, i.e., the isolation and selection of biological control agents from healthy plants, or from the disease-suppressive soil for the construction of synthetic microbial communities, and the integration of synthetic microbial communities with various strategies, including seed coating, root dipping, seedling substrate, soil drenching, foliar spraying, and application as a bio-organic fertilizer. By adopting these strategies, we aim to provide proactive and efficient approaches for combating macadamia decline and safeguarding the health of macadamia orchards.

Plants are best understood as evolutionary holobionts, in which the host and its associated microbiomes operate as an integrated unit to influence growth, health, and stress resilience. This comprehensive review synthesizes the most current knowledge of plant‐associated microbiomes across key ecological compartments, including the rhizosphere, endosphere, phyllosphere, and seeds, highlighting their assembly drivers, functional mechanisms, and translational potential. We dissect the molecular foundations of rhizobial and arbuscular mycorrhizal (AM) symbioses, the plant‐AM fungus‐bacterium continuum, alongside emerging concepts including the aerial root mucilagesphere, phyllosphere homeostasis, and the pathobiome. We further explore host genetic, metabolic, and environmental determinants of microbiome assembly, and present cutting‐edge methodologies ranging from quantitative profiling to artificial intelligence‐driven synthetic community design. Finally, we outline a strategic blueprint for harnessing standardized synthetic microbiomes and precision microbiome engineering to advance sustainable agriculture. This integrative framework bridges fundamental ecology with practical applications, delineating a path toward climate‐resilient crop production.

Social media platforms have revolutionized scientific communication by bridging gaps between researchers, academic journals, and global audiences. This article showcases iMeta, an open-access journal that leverages a diversified social media framework to enhance bilingual dissemination, boost full-text downloads, and amplify international influence. Since its editorial board founded, iMeta has achieved a series of milestones: integrating platforms like WeChat, Bilibili, X (formerly Twitter), YouTube, and BlueSky; launching iMeta-branded journals iMetaOmics and iMetaMed; and being indexed in prominent databases including PubMed, SCIE, and ESI. As of August 2025, the journal has recorded 1,334,761 full-text downloads and 10,560 total citations, with a 2024 impact factor of 33.2. A significant positive correlation between downloads and citations highlights how strategic social media integration and iMeta's growth drive visibility and influence, positioning it as a leading journal in its field.

We employed an 18-month pot experiment and an integrated multi-omics approach to elucidate the potential mechanisms underlying synthetic community (SynCom)-mediated macadamia growth promotion. SynCom inoculation enhanced soil nitrogen cycling and potential nutrient (e.g., iron) acquisition. It simultaneously increased soil extracellular enzyme activities and enriched beneficial bacteria such as Rhodanobacter, Ferrovibrio, and Rhodoblastus in the root compartment. In addition, SynCom inoculation promoted the accumulation of rhizosphere metabolites, including the microbial siderophore pyochelin, and drove the co-enrichment of transcriptomic and metabolomic pathways, notably the arginine biosynthesis pathway. This coordinated response may have stimulated nitrogen and iron cycling in the soil, thereby promoting the healthy growth of macadamia.