Jaime Ramón-Costa

Mr. Jaime Ramón-Costa

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Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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14 November 2023 in Molecules
Verified
Journal Article
Open access
PDF file
ADAna Donaire-Arias
Ana Donaire-Arias
MPMartin L. Poulsen
Martin L. Poulsen
JRJaime Ramón-Costa
Jaime Ramón-Costa
AMAna Maria Montagut
Ana Maria Montagut
RERoger Estrada-Tejedor
Roger Estrada-Tejedor
JBJose I. Borrell
Jose I. Borrell
Chalcones are a type of molecule that can be considered as easily synthesizable through aldol condensation or that can be readily purchased from habitual commercial vendors. However, on reviewing the literature, one realizes that there are no standard procedures for such aldol condensations, that there exists a wide range of alternative methods for the aldol condensation (indicating that such a condensation is not always simple), and that, in many cases, low yields are obtained that involve purifications by recrystallization or column chromatography. To develop a robust standard protocol independent of the nature of the substituents present on the acetophenone or the benzaldehyde involved in the aldol condensation leading to the chalcone, we made a comparison between an aldol condensation in KOH/EtOH and a Wittig reaction between the corresponding ylide and benzaldehyde in water. We describe an improved procedure for the Wittig reaction and a protocol for the elimination of the Ph3P=O byproduct (and the excess of ylide used) by filtration of the crude reaction product through a silica gel plug. We thus demonstrate that such an improved procedure can be a general method for the synthesis of chalcones in high yield and excellent purity and is clearly an improvement on the classical aldol condensation.