Among obesity, cumulative fat and poor physical activity are risk factors for cardiovascular disease. Due to the limit in performing aerobic exercise (AER), whole-body vibration (WBV) as a passive form of exercise is an alternative therapeutic strategy. Herein, this study aimed to compare the immediate effects of AER and WBV on metabolic and cardiovascular responses, and dyspnea level in obesity. Forty-nine eligible obesities performed both AER and WBV, with a random order assignment (age = 28.94 ± 11.39 years). Fat oxidation, cardiovascular parameters (i.e., heart rate (HR) and blood pressure (BP)), and dyspnea level (i.e., rating perceived exertion (RPE)) were measured during exercise, while lipid mobilization (i.e., triglycerides) was collected pre- and post-exercise. Fat oxidation rate in AER was significantly higher than in WBV. Significantly increased fat oxidation rates were shown in both groups (within-group analyses) (also shown in females aged 20–45). Triglyceride levels between AER and WBV were similar. A significant decrease in triglyceride levels was only observed in WBV (within-group change). HR and RPE in AER were significantly higher than in WBV (p < 0.05). HR and RPE were significantly increased throughout both AER and WBV, while systolic blood pressure was only significantly elevated in AER (whining-group analyses). WBV may facilitate fat oxidation (particularly in females aged below 45), induce lipid mobilization, and reduce interference on cardiovascular parameters in obesity.

As stroke survivors often manifest not only physical dysfunction but also cognitive impairment, interventions that address both physical and cognitive aspects may be beneficial for individuals with chronic stroke. However, a randomized clinical trial (RCT) examining the effects of physical–cognitive telerehabilitation exergaming across physical and cognitive domains in chronic stroke survivors remains scarce. Therefore, this study aims to investigate the effectiveness of the web-based physical–cognitive telerehabilitation exergaming on the physical and cognitive performance of chronic stroke survivors as compared to control. A two-arm RCT with a blinded assessor will be conducted. Fifty-two participants will be randomly assigned to either the intervention or the control group. Participants in the intervention group will receive a 12-week training program, whereas those in the control group will continue with usual care. Motor function, gait speed, balance, fall risk, muscle power, weight distribution, body composition, global cognition, executive function, attention, memory, as well as enjoyment will be assessed. Existing evidence has established the health benefits of physical–cognitive exergaming. It is expected that a physical–cognitive exergaming program may further exhibit positive effects on both physical function and cognition beyond the results of usual care. In addition, incorporating physical–cognitive training into a web-based telerehabilitation program may improve adherence and provide a feasible and enjoyable rehabilitation option for individuals with chronic stroke.

Background/Objectives: Although the adverse metabolic effects of PM2.5 and the health benefits of physical activity are well-established, evidence on whether physical activity modifies the association between PM2.5 exposure and metabolic syndrome or health-related quality of life (HRQoL) remains limited. Methods: This observational analytical cross-sectional study examined the modifying effect of physical activity on the associations between long-term PM2.5 exposure and metabolic syndrome and HRQoL in Chiang Mai, Thailand, and to explore these associations across physical activity levels using stratified analyses. A total of 347 participants (209 from higher PM2.5 areas and 138 from lower PM2.5 areas) were recruited in Chiang Mai between March and May 2024. Metabolic syndrome was assessed using blood tests and anthropometric measurement, while HRQoL was evaluated using the Thai version of the SF-36 questionnaire. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for metabolic syndrome. HRQoL differences were analyzed using generalized linear models with robust standard errors. Interaction between PM2.5 exposure and physical activity was assessed to examine potential effect modification. All models were adjusted for age, sex, BMI, smoking status, and educational level, with additional stratified analyses across physical activity levels. Results: Higher long-term PM2.5 exposure was associated with lower odds of metabolic syndrome (OR = 0.34, 95% CI: 0.14–0.83) but was not associated with HRQoL. Physical activity was not independently associated with either outcome, and no interaction between PM2.5 exposure and physical activity was observed. In stratified analyses, the inverse association between PM2.5 exposure and metabolic syndrome was observed only among individuals with high physical activity, while significantly lower HRQoL scores were observed among those with moderate and high physical activity levels. Conclusions: Higher long-term PM2.5 exposure was associated with lower odds of metabolic syndrome and lower HRQoL. Physical activity was not independently associated with these outcomes, and no interaction between PM2.5 exposure and physical activity was observed. Stratified analyses suggested variation in these associations across physical activity levels.